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- W1557274850 endingPage "806" @default.
- W1557274850 startingPage "798" @default.
- W1557274850 abstract "Transcription factor binding sites (TFBSs) on the DNA are generally accepted as the key nodes of gene control. However, the multitudes of TFBSs identified in genome-wide studies, some of them seemingly unconstrained in evolution, have prompted the view that in many cases TF binding may serve no biological function. Yet, insights from transcriptional biochemistry, population genetics and functional genomics suggest that rather than segregating into ‘functional’ or ‘non-functional’, TFBS inputs to their target genes may be generally cumulative, with varying degrees of potency and redundancy. As TFBS redundancy can be diminished by mutations and environmental stress, some of the apparently ‘spurious’ sites may turn out to be important for maintaining adequate transcriptional regulation under these conditions. This has significant implications for interpreting the phenotypic effects of TFBS mutations, particularly in the context of genome-wide association studies for complex traits." @default.
- W1557274850 created "2016-06-24" @default.
- W1557274850 creator A5074679629 @default.
- W1557274850 date "2014-05-30" @default.
- W1557274850 modified "2023-10-16" @default.
- W1557274850 title "Spurious transcription factor binding: Non‐functional or genetically redundant?" @default.
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