FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1557348363> ?p ?o ?g. }

• W1557348363 endingPage "886" @default.
• W1557348363 startingPage "876" @default.
• W1557348363 abstract "Imidazole‐based compounds previously synthesized in our laboratory were selected and reconsidered as inhibitors of heme oxygenase‐1 obtained from the microsomal fractions of rat spleens. Most of tested compounds were good inhibitors with IC 50 values in the low micromolar range. Compounds were also assayed on membrane‐free full‐length recombinant human heme oxygenase‐1; all tested compounds were unable to interact with human heme oxygenase‐1 at 100 μ m concentrations with the exception of compounds 11 and 13 that inhibited the enzyme of 54% and 20%, respectively. The binding of the most active compound 11 with heme or heme‐conjugated human heme oxygenase‐1 was also examined by spectral analyses. When heme was not conjugated to human heme oxygenase‐1, compound 11 caused changes in the heme spectrum only at concentration 50‐fold (100 μ m ) higher than that required to inhibit rat heme oxygenase‐1; when heme was conjugated to human heme oxygenase‐1, compound 11 was able to form a heme‐compound 11 complex also at low micromolar concentrations. To obtain information on the binding mode of the tested compounds with enzyme, docking studies and pharmacophore analysis were performed. Template docking results were in agreement with experimental inhibition data and with a structure‐based pharmacophoric model. These data may be exploitable to design new OH‐1 inhibitors." @default.
• W1557348363 created "2016-06-24" @default.
• W1557348363 creator A5004982672 @default.
• W1557348363 creator A5018322905 @default.
• W1557348363 creator A5040847244 @default.
• W1557348363 creator A5056771219 @default.
• W1557348363 creator A5065218357 @default.
• W1557348363 creator A5066691562 @default.
• W1557348363 creator A5084855762 @default.
• W1557348363 creator A5086602723 @default.
• W1557348363 creator A5089653689 @default.
• W1557348363 date "2012-10-09" @default.
• W1557348363 modified "2023-10-16" @default.
• W1557348363 title "Evaluation of Imidazole-Based Compounds as Heme Oxygenase-1 Inhibitors" @default.
• W1557348363 cites W1551183882 @default.
• W1557348363 cites W1591240009 @default.
• W1557348363 cites W1775749144 @default.
• W1557348363 cites W1918909434 @default.
• W1557348363 cites W1964850221 @default.
• W1557348363 cites W1966884476 @default.
• W1557348363 cites W1971572370 @default.
• W1557348363 cites W1972442898 @default.
• W1557348363 cites W1972487105 @default.
• W1557348363 cites W1980351331 @default.
• W1557348363 cites W1983095597 @default.
• W1557348363 cites W1986332480 @default.
• W1557348363 cites W1987991824 @default.
• W1557348363 cites W1990314210 @default.
• W1557348363 cites W2002095463 @default.
• W1557348363 cites W2002546148 @default.
• W1557348363 cites W2005904261 @default.
• W1557348363 cites W2007032695 @default.
• W1557348363 cites W2012434885 @default.
• W1557348363 cites W2014308014 @default.
• W1557348363 cites W2020370096 @default.
• W1557348363 cites W2020941408 @default.
• W1557348363 cites W2022223406 @default.
• W1557348363 cites W2023366190 @default.
• W1557348363 cites W2024416107 @default.
• W1557348363 cites W2025541083 @default.
• W1557348363 cites W2028778467 @default.
• W1557348363 cites W2031702197 @default.
• W1557348363 cites W2034385668 @default.
• W1557348363 cites W2035673692 @default.
• W1557348363 cites W2043855224 @default.
• W1557348363 cites W2048830743 @default.
• W1557348363 cites W2054802842 @default.
• W1557348363 cites W2055315590 @default.
• W1557348363 cites W2056523101 @default.
• W1557348363 cites W2056916650 @default.
• W1557348363 cites W2064063264 @default.
• W1557348363 cites W2080581246 @default.
• W1557348363 cites W2084017433 @default.
• W1557348363 cites W2084494271 @default.
• W1557348363 cites W2094312617 @default.
• W1557348363 cites W2114367386 @default.
• W1557348363 cites W2124433916 @default.
• W1557348363 cites W2126421125 @default.
• W1557348363 cites W2137130674 @default.
• W1557348363 cites W2145995488 @default.
• W1557348363 cites W2161202118 @default.
• W1557348363 cites W2166560642 @default.
• W1557348363 cites W2168799718 @default.
• W1557348363 cites W2170875710 @default.
• W1557348363 cites W2175160998 @default.
• W1557348363 cites W2208203352 @default.
• W1557348363 cites W817522 @default.
• W1557348363 cites W88024062 @default.
• W1557348363 doi "https://doi.org/10.1111/cbdd.12015" @default.
• W1557348363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22882835" @default.
• W1557348363 hasPublicationYear "2012" @default.
• W1557348363 type Work @default.
• W1557348363 sameAs 1557348363 @default.
• W1557348363 citedByCount "29" @default.
• W1557348363 countsByYear W15573483632013 @default.
• W1557348363 countsByYear W15573483632015 @default.
• W1557348363 countsByYear W15573483632017 @default.
• W1557348363 countsByYear W15573483632018 @default.
• W1557348363 countsByYear W15573483632019 @default.
• W1557348363 countsByYear W15573483632020 @default.
• W1557348363 countsByYear W15573483632021 @default.
• W1557348363 countsByYear W15573483632022 @default.
• W1557348363 countsByYear W15573483632023 @default.
• W1557348363 crossrefType "journal-article" @default.
• W1557348363 hasAuthorship W1557348363A5004982672 @default.
• W1557348363 hasAuthorship W1557348363A5018322905 @default.
• W1557348363 hasAuthorship W1557348363A5040847244 @default.
• W1557348363 hasAuthorship W1557348363A5056771219 @default.
• W1557348363 hasAuthorship W1557348363A5065218357 @default.
• W1557348363 hasAuthorship W1557348363A5066691562 @default.
• W1557348363 hasAuthorship W1557348363A5084855762 @default.
• W1557348363 hasAuthorship W1557348363A5086602723 @default.
• W1557348363 hasAuthorship W1557348363A5089653689 @default.
• W1557348363 hasBestOaLocation W15573483631 @default.
• W1557348363 hasConcept C159110408 @default.
• W1557348363 hasConcept C165474305 @default.
• W1557348363 hasConcept C181199279 @default.
• W1557348363 hasConcept C185592680 @default.

• next