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• W1557389622 endingPage "4922" @default.
• W1557389622 startingPage "4914" @default.
• W1557389622 abstract "Abstract The aim of this study was to identify molecular mechanisms involved in transcriptional regulation of IL-2 expression following CD2 and CD3 activation in lamina propria (LP) T cells. Studies used T cells from normal, ulcerative colitis, and Crohn’s disease mucosa and freshly isolated PBMC, PBMC stimulated with IL-2 alone, and PBMC stimulated with IL-2 and cocultured with B cell lines (LP-like T cells). Electrophoretic mobility shift assays were performed with nuclear extracts from cells activated with either anti-CD2 or anti-CD3 Abs. CD2 signaling in LPMC and LP-like T cells led to a pattern of sustained up-regulation of AP-1-binding complexes, whereas CD3 activation resulted in only transient up-regulation. While the pattern of regulation of AP-1 binding observed in normal, uninflamed, or inflamed Crohn’s disease LPMC is similar, differences in intensity of AP-1 binding were observed. Activation of LP-like T cells mimics the up-regulation of AP-1 with a kinetic profile similar to that observed with freshly isolated LPMC from Crohn’s disease-inflamed tissue. The AP-1 complex formed following CD2 activation is composed of jun/fos heterodimers. The CD2-enhanced responsiveness is reflected in functional analysis experiments utilizing transfection of both multimeric-TRE or IL-2 promoter-luciferase constructs directly into normal, ulcerative colitis, or Crohn’s disease LPMC. Our data suggest that activation of LP T cells from normal, ulcerative colitis, or Crohn’s disease mucosa through the CD2 pathway leads to induction of AP-1 complexes that bind to the IL-2 promoter, and may play a pivotal role in modulating IL-2 production in the gut." @default.
• W1557389622 created "2016-06-24" @default.
• W1557389622 creator A5030305499 @default.
• W1557389622 creator A5051870878 @default.
• W1557389622 creator A5083799837 @default.
• W1557389622 creator A5090080497 @default.
• W1557389622 date "1998-05-15" @default.
• W1557389622 modified "2023-10-11" @default.
• W1557389622 title "Activation of the CD2 Pathway in Lamina Propria T Cells Up-Regulates Functionally Active AP-1 Binding to the IL-2 Promoter, Resulting in Messenger RNA Transcription and IL-2 Secretion" @default.
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• W1557389622 doi "https://doi.org/10.4049/jimmunol.160.10.4914" @default.
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• W1557389622 hasPublicationYear "1998" @default.
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