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• W1557401501 abstract "Abstract When cells of the marine pseudomonad B-16 (ATCC 19855) grown in nutrient broth-salts medium containing 0.01 m KCl, were washed in a complete salts solution consisting of 0.3 m NaCl, 0.05 m MgSO4, and 0.01 m KCl the intracellular K+ concentration was approximately 0.3 m and the cells rapidly accumulated α-aminoisobutyric acid-14C (AIB-14C). Cells washed with 0.05 m MgSO4 solution alone lost some 95 to 98% of the total intracellular K+. Transport studies revealed that K+-depleted cells resuspended in salts solution containing 0.3 m NaCl, 0.05 m MgSO4, and 0.05 m Tris-HCl buffer (pH 7.2) failed to accumulate AIB-14C. Penetration studies under these conditions showed that α-aminoisobutyric acid (AIB) nevertheless entered the cells, and occupied the total available fluid space in a packed cell preparation of K+-depleted cells. Entry of AIB was Na+ dependent, and equivalent concentrations of Li+ or K+ failed to replace this cation in mediating AIB penetration and equilibration. Addition of K+ to the equilibrated system resulted in rapid accumulation of the substrate. The rate of AIB accumulation was maximal at 0.01 m KCl and kinetic analysis revealed that K+ increased Vmax but did not change the Km for transport. Additions of adenine nucleotides further increased the rate of AIB accumulation in the presence but not in the absence of K+. When K+-depleted cells were again loaded with K+ and subsequently transferred to AIB uptake medium lacking K+, there was immediate and rapid accumulation of substrate. Active transport of AIB is apparently mediated by two distinct cation-dependent steps. The first stage involves the entry and equilibration of AIB into the cells by a Na+-dependent facilitated diffusion mechanism. In the K+-dependent second stage, the cation, acting at the intracellular level, brings about the accumulation of AIB against a concentration gradient." @default.
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• W1557401501 date "1971-06-01" @default.
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• W1557401501 title "Functions of Na+ and K+ in the Active Transport of α-Aminoisobutyric Acid in a Marine Pseudomonad" @default.
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• W1557401501 doi "https://doi.org/10.1016/s0021-9258(18)62141-6" @default.
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