FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1557524937> ?p ?o ?g. }

• W1557524937 endingPage "19527" @default.
• W1557524937 startingPage "19521" @default.
• W1557524937 abstract "G protein-coupled receptor kinases (GRK), such as the beta-adrenergic receptor kinase (beta ARK) and rhodopsin kinase, specifically phosphorylate the activated form of G protein-coupled receptors. To identify additional members of the GRK family, we screened a human heart cDNA library by low stringency hybridization using the catalytic domains of two beta ARK isoforms. Here we report the isolation of a cDNA that encodes a 576-amino-acid protein kinase, termed GRK6, that has significant homology with GRK5 (70.1% amino acid identity), IT11 (68.5%), rhodopsin kinase (47.1%), and beta ARK (37.4%). RNA blot analysis of GRK6 with selected human tissues reveals two distinct mRNAs of 3 and 2.4 kilobases with a distribution very similar to that of beta ARK (i.e. brain, skeletal muscle > pancreas > heart, lung, kidney, placenta > liver). GRK6, overexpressed in Sf9 insect cells using the baculovirus system, was able to phosphorylate both the beta 2-adrenergic receptor and rhodopsin in a stimulus-dependent fashion, although it was significantly less active then beta ARK on these substrates. These data extend the family of GRKs and suggest that GRK6 may have a substrate specificity quite distinct from beta ARK and rhodopsin kinase." @default.
• W1557524937 created "2016-06-24" @default.
• W1557524937 creator A5035941891 @default.
• W1557524937 creator A5056161061 @default.
• W1557524937 date "1993-09-01" @default.
• W1557524937 modified "2023-10-13" @default.
• W1557524937 title "Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family." @default.
• W1557524937 cites W1014698510 @default.
• W1557524937 cites W1485523393 @default.
• W1557524937 cites W1497519474 @default.
• W1557524937 cites W1514710040 @default.
• W1557524937 cites W1528193286 @default.
• W1557524937 cites W1530935792 @default.
• W1557524937 cites W1533788848 @default.
• W1557524937 cites W1538620682 @default.
• W1557524937 cites W1563425172 @default.
• W1557524937 cites W1603981767 @default.
• W1557524937 cites W182149432 @default.
• W1557524937 cites W1904128007 @default.
• W1557524937 cites W1945832201 @default.
• W1557524937 cites W1963816294 @default.
• W1557524937 cites W1969153299 @default.
• W1557524937 cites W1969380986 @default.
• W1557524937 cites W1971062754 @default.
• W1557524937 cites W1983908525 @default.
• W1557524937 cites W1993755473 @default.
• W1557524937 cites W2006718599 @default.
• W1557524937 cites W2032221545 @default.
• W1557524937 cites W2040452518 @default.
• W1557524937 cites W2043153319 @default.
• W1557524937 cites W2047896617 @default.
• W1557524937 cites W2070738247 @default.
• W1557524937 cites W2071132058 @default.
• W1557524937 cites W2072842460 @default.
• W1557524937 cites W2075398040 @default.
• W1557524937 cites W2084704570 @default.
• W1557524937 cites W2086617442 @default.
• W1557524937 cites W2092964019 @default.
• W1557524937 cites W2100837269 @default.
• W1557524937 cites W2116949924 @default.
• W1557524937 cites W2132897827 @default.
• W1557524937 cites W2138270253 @default.
• W1557524937 cites W2140220315 @default.
• W1557524937 cites W2140246136 @default.
• W1557524937 cites W2149464986 @default.
• W1557524937 doi "https://doi.org/10.1016/s0021-9258(19)36546-9" @default.
• W1557524937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8366096" @default.
• W1557524937 hasPublicationYear "1993" @default.
• W1557524937 type Work @default.
• W1557524937 sameAs 1557524937 @default.
• W1557524937 citedByCount "123" @default.
• W1557524937 countsByYear W15575249372012 @default.
• W1557524937 countsByYear W15575249372013 @default.
• W1557524937 countsByYear W15575249372014 @default.
• W1557524937 countsByYear W15575249372015 @default.
• W1557524937 countsByYear W15575249372016 @default.
• W1557524937 countsByYear W15575249372017 @default.
• W1557524937 countsByYear W15575249372018 @default.
• W1557524937 countsByYear W15575249372019 @default.
• W1557524937 countsByYear W15575249372020 @default.
• W1557524937 countsByYear W15575249372021 @default.
• W1557524937 countsByYear W15575249372022 @default.
• W1557524937 crossrefType "journal-article" @default.
• W1557524937 hasAuthorship W1557524937A5035941891 @default.
• W1557524937 hasAuthorship W1557524937A5056161061 @default.
• W1557524937 hasBestOaLocation W15575249371 @default.
• W1557524937 hasConcept C121050878 @default.
• W1557524937 hasConcept C135285700 @default.
• W1557524937 hasConcept C185592680 @default.
• W1557524937 hasConcept C199360897 @default.
• W1557524937 hasConcept C33235085 @default.
• W1557524937 hasConcept C41008148 @default.
• W1557524937 hasConcept C62478195 @default.
• W1557524937 hasConcept C86803240 @default.
• W1557524937 hasConcept C95444343 @default.
• W1557524937 hasConceptScore W1557524937C121050878 @default.
• W1557524937 hasConceptScore W1557524937C135285700 @default.
• W1557524937 hasConceptScore W1557524937C185592680 @default.
• W1557524937 hasConceptScore W1557524937C199360897 @default.
• W1557524937 hasConceptScore W1557524937C33235085 @default.
• W1557524937 hasConceptScore W1557524937C41008148 @default.
• W1557524937 hasConceptScore W1557524937C62478195 @default.
• W1557524937 hasConceptScore W1557524937C86803240 @default.
• W1557524937 hasConceptScore W1557524937C95444343 @default.
• W1557524937 hasIssue "26" @default.
• W1557524937 hasLocation W15575249371 @default.
• W1557524937 hasOpenAccess W1557524937 @default.
• W1557524937 hasPrimaryLocation W15575249371 @default.
• W1557524937 hasRelatedWork W1531601525 @default.
• W1557524937 hasRelatedWork W2319480705 @default.
• W1557524937 hasRelatedWork W2384464875 @default.
• W1557524937 hasRelatedWork W2606230654 @default.
• W1557524937 hasRelatedWork W2607424097 @default.
• W1557524937 hasRelatedWork W2748952813 @default.
• W1557524937 hasRelatedWork W2899084033 @default.
• W1557524937 hasRelatedWork W2948807893 @default.
• W1557524937 hasRelatedWork W4387497383 @default.
• W1557524937 hasRelatedWork W2778153218 @default.

• next