Matches in SemOpenAlex for { <https://semopenalex.org/work/W1557548215> ?p ?o ?g. }
- W1557548215 endingPage "40" @default.
- W1557548215 startingPage "734" @default.
- W1557548215 abstract "Inhibition of cyclooxygenase (COX) activity decreases eicosanoid production and prevents lung cancer in animal models. Prostaglandin (PG) I(2) (PGI(2), prostacyclin) is a PGH(2) metabolite with anti-inflammatory, antiproliferative, and antimetastatic properties. The instability of PGI(2) has limited its evaluation in animal models of cancer. We hypothesized that pulmonary overexpression of prostacyclin synthase may prevent the development of murine lung tumors. Transgenic mice with selective pulmonary prostacyclin synthase overexpression were exposed to two distinct carcinogenesis protocols: an initiation/promotion model and a simple carcinogen model. The transgenic mice exhibited significantly reduced lung tumor multiplicity (tumor number) in proportion to transgene expression, a dose-response effect. Moreover, the highest expressing mice demonstrated reduced tumor incidence. To investigate the mechanism for protection, we evaluated PG levels and inflammatory responses. At the time of sacrifice following one carcinogenesis model, the transgenics exhibited only an increase in 6-keto-PGF(1alpha), not a decrease in PGE(2). Thus, elevated PGI(2) levels and not decreased PGE(2) levels appear to be necessary for the chemopreventive effects. When exposed to a single dose of butylated hydroxytoluene, transgenic mice exhibited a survival advantage; however, reduction in alveolar inflammatory response was not observed. These studies demonstrate that manipulation of PG metabolism downstream from COX produces even more profound lung cancer reduction than COX inhibition alone and could be the basis for new approaches to understanding the pathogenesis and prevention of lung cancer." @default.
- W1557548215 created "2016-06-24" @default.
- W1557548215 creator A5008812839 @default.
- W1557548215 creator A5020425226 @default.
- W1557548215 creator A5022054266 @default.
- W1557548215 creator A5033309667 @default.
- W1557548215 creator A5047707609 @default.
- W1557548215 creator A5062547544 @default.
- W1557548215 creator A5072704172 @default.
- W1557548215 creator A5081200050 @default.
- W1557548215 creator A5083552255 @default.
- W1557548215 creator A5085283368 @default.
- W1557548215 date "2002-02-01" @default.
- W1557548215 modified "2023-10-01" @default.
- W1557548215 title "Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer." @default.
- W1557548215 cites W1456663821 @default.
- W1557548215 cites W1525444530 @default.
- W1557548215 cites W1556164808 @default.
- W1557548215 cites W1775749144 @default.
- W1557548215 cites W1945848242 @default.
- W1557548215 cites W1968424525 @default.
- W1557548215 cites W1969271268 @default.
- W1557548215 cites W1977666051 @default.
- W1557548215 cites W1981581994 @default.
- W1557548215 cites W1989934461 @default.
- W1557548215 cites W1990345361 @default.
- W1557548215 cites W2004127755 @default.
- W1557548215 cites W2004794022 @default.
- W1557548215 cites W2014240993 @default.
- W1557548215 cites W2024233889 @default.
- W1557548215 cites W2035810647 @default.
- W1557548215 cites W2037858851 @default.
- W1557548215 cites W2039172749 @default.
- W1557548215 cites W2047100184 @default.
- W1557548215 cites W2049169085 @default.
- W1557548215 cites W2068467321 @default.
- W1557548215 cites W2068806248 @default.
- W1557548215 cites W2074444579 @default.
- W1557548215 cites W2074911914 @default.
- W1557548215 cites W2080913628 @default.
- W1557548215 cites W2085052924 @default.
- W1557548215 cites W2114597279 @default.
- W1557548215 cites W2132175919 @default.
- W1557548215 cites W2133592787 @default.
- W1557548215 cites W2135510321 @default.
- W1557548215 cites W2138178697 @default.
- W1557548215 cites W2142144238 @default.
- W1557548215 cites W2154676215 @default.
- W1557548215 cites W2156901963 @default.
- W1557548215 cites W2315403385 @default.
- W1557548215 cites W2317242858 @default.
- W1557548215 cites W2321522617 @default.
- W1557548215 cites W2322620650 @default.
- W1557548215 cites W2330709704 @default.
- W1557548215 cites W2336160773 @default.
- W1557548215 cites W2407825386 @default.
- W1557548215 cites W2415335584 @default.
- W1557548215 cites W2417902007 @default.
- W1557548215 cites W2470929789 @default.
- W1557548215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11830527" @default.
- W1557548215 hasPublicationYear "2002" @default.
- W1557548215 type Work @default.
- W1557548215 sameAs 1557548215 @default.
- W1557548215 citedByCount "56" @default.
- W1557548215 countsByYear W15575482152013 @default.
- W1557548215 countsByYear W15575482152015 @default.
- W1557548215 countsByYear W15575482152016 @default.
- W1557548215 countsByYear W15575482152017 @default.
- W1557548215 countsByYear W15575482152018 @default.
- W1557548215 countsByYear W15575482152019 @default.
- W1557548215 countsByYear W15575482152021 @default.
- W1557548215 countsByYear W15575482152022 @default.
- W1557548215 countsByYear W15575482152023 @default.
- W1557548215 crossrefType "journal-article" @default.
- W1557548215 hasAuthorship W1557548215A5008812839 @default.
- W1557548215 hasAuthorship W1557548215A5020425226 @default.
- W1557548215 hasAuthorship W1557548215A5022054266 @default.
- W1557548215 hasAuthorship W1557548215A5033309667 @default.
- W1557548215 hasAuthorship W1557548215A5047707609 @default.
- W1557548215 hasAuthorship W1557548215A5062547544 @default.
- W1557548215 hasAuthorship W1557548215A5072704172 @default.
- W1557548215 hasAuthorship W1557548215A5081200050 @default.
- W1557548215 hasAuthorship W1557548215A5083552255 @default.
- W1557548215 hasAuthorship W1557548215A5085283368 @default.
- W1557548215 hasConcept C102230213 @default.
- W1557548215 hasConcept C104317684 @default.
- W1557548215 hasConcept C114246631 @default.
- W1557548215 hasConcept C121608353 @default.
- W1557548215 hasConcept C126322002 @default.
- W1557548215 hasConcept C134018914 @default.
- W1557548215 hasConcept C141035611 @default.
- W1557548215 hasConcept C181199279 @default.
- W1557548215 hasConcept C185592680 @default.
- W1557548215 hasConcept C2776256026 @default.
- W1557548215 hasConcept C2776352991 @default.
- W1557548215 hasConcept C2778078955 @default.
- W1557548215 hasConcept C2779689624 @default.
- W1557548215 hasConcept C2780664492 @default.