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- W1557771170 abstract "Common fragile sites are specific deoxyribonucleic acid (DNA) breakage-prone genomic regions in all healthy humans. Their instability is provoked by replication stress combined with an escape of cell cycle checkpoints. Common fragile sites are favoured regions of chromosomal aberration formation in the neoplastic process. They are inherent parts of the genomes of all so far analysed mammalian species, and recent data support their existence also in yeast. The common fragile site locations are highly conserved between human and other primates as well as between human and mouse. There is no evidence of an involvement of common fragile sites as ‘hotspots’ in chromosome evolution." @default.
- W1557771170 created "2016-06-24" @default.
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- W1557771170 date "2008-03-14" @default.
- W1557771170 modified "2023-09-26" @default.
- W1557771170 title "Evolution of Common Fragile Sites" @default.
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- W1557771170 doi "https://doi.org/10.1002/9780470015902.a0020747" @default.
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