Matches in SemOpenAlex for { <https://semopenalex.org/work/W1557784023> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1557784023 endingPage "115.6" @default.
- W1557784023 startingPage "115.6" @default.
- W1557784023 abstract "Abstract Invariant Natural Killer T (iNKT) cells are potent regulators of diverse immune responses. Our previous study indicated that lack of miRNAs following the deletion of Dicer, a miRNAs-processing enzyme, affect iNKT cell development and function. However, the roles of specific miRNA in iNKT cell development and function has not been reported. To identify which miRNAs are involved in NKT cell development, we first performed a genome-wide miRNA expression profiling during NKT cell development and found that miR-155 was highly expressed in early iNKT cell development, followed by a sharp decrease in late developmental stage in thymus. To test the role of miR-155 in iNKT cells, two miR155 mutant mouse models had been used. With a conventional miR-155 deficient mouse model, we did not find remarkable defects of iNKT cell development and function. However, overexpression of miR-155 in bone marrow or thymus results in iNKT cell developmental defect in the thymus without dramatic effects on other immune cells. Furthermore, miR-155 overexpressed iNKT cells display profound defects in their cytokine production. Bone marrow from miR-155 overexpressed mice poorly reconstituted iNKT cells, suggesting a cell intrinsic effect. Finally, we have identified Itk (Inducible T cell Kinase) as a direct target of miR-155 in the regulation of iNKT cell development and function. Together, our data suggest that dynamic regulation of miR-155 expression is required for iNKT cell development and function." @default.
- W1557784023 created "2016-06-24" @default.
- W1557784023 creator A5005416804 @default.
- W1557784023 creator A5024598893 @default.
- W1557784023 creator A5051363890 @default.
- W1557784023 creator A5076317415 @default.
- W1557784023 creator A5079661879 @default.
- W1557784023 creator A5080712099 @default.
- W1557784023 date "2012-05-01" @default.
- W1557784023 modified "2023-10-03" @default.
- W1557784023 title "microRNA miR-155 regulates NKT cell development and function by targeting ITK (115.6)" @default.
- W1557784023 doi "https://doi.org/10.4049/jimmunol.188.supp.115.6" @default.
- W1557784023 hasPublicationYear "2012" @default.
- W1557784023 type Work @default.
- W1557784023 sameAs 1557784023 @default.
- W1557784023 citedByCount "0" @default.
- W1557784023 crossrefType "journal-article" @default.
- W1557784023 hasAuthorship W1557784023A5005416804 @default.
- W1557784023 hasAuthorship W1557784023A5024598893 @default.
- W1557784023 hasAuthorship W1557784023A5051363890 @default.
- W1557784023 hasAuthorship W1557784023A5076317415 @default.
- W1557784023 hasAuthorship W1557784023A5079661879 @default.
- W1557784023 hasAuthorship W1557784023A5080712099 @default.
- W1557784023 hasConcept C104317684 @default.
- W1557784023 hasConcept C139563560 @default.
- W1557784023 hasConcept C145059251 @default.
- W1557784023 hasConcept C1491633281 @default.
- W1557784023 hasConcept C203014093 @default.
- W1557784023 hasConcept C22615655 @default.
- W1557784023 hasConcept C2776090121 @default.
- W1557784023 hasConcept C2779867133 @default.
- W1557784023 hasConcept C54009773 @default.
- W1557784023 hasConcept C54355233 @default.
- W1557784023 hasConcept C62112901 @default.
- W1557784023 hasConcept C81885089 @default.
- W1557784023 hasConcept C86803240 @default.
- W1557784023 hasConcept C8891405 @default.
- W1557784023 hasConcept C95444343 @default.
- W1557784023 hasConceptScore W1557784023C104317684 @default.
- W1557784023 hasConceptScore W1557784023C139563560 @default.
- W1557784023 hasConceptScore W1557784023C145059251 @default.
- W1557784023 hasConceptScore W1557784023C1491633281 @default.
- W1557784023 hasConceptScore W1557784023C203014093 @default.
- W1557784023 hasConceptScore W1557784023C22615655 @default.
- W1557784023 hasConceptScore W1557784023C2776090121 @default.
- W1557784023 hasConceptScore W1557784023C2779867133 @default.
- W1557784023 hasConceptScore W1557784023C54009773 @default.
- W1557784023 hasConceptScore W1557784023C54355233 @default.
- W1557784023 hasConceptScore W1557784023C62112901 @default.
- W1557784023 hasConceptScore W1557784023C81885089 @default.
- W1557784023 hasConceptScore W1557784023C86803240 @default.
- W1557784023 hasConceptScore W1557784023C8891405 @default.
- W1557784023 hasConceptScore W1557784023C95444343 @default.
- W1557784023 hasIssue "1_Supplement" @default.
- W1557784023 hasLocation W15577840231 @default.
- W1557784023 hasOpenAccess W1557784023 @default.
- W1557784023 hasPrimaryLocation W15577840231 @default.
- W1557784023 hasRelatedWork W1648324402 @default.
- W1557784023 hasRelatedWork W2062057385 @default.
- W1557784023 hasRelatedWork W2083693850 @default.
- W1557784023 hasRelatedWork W2973099012 @default.
- W1557784023 hasRelatedWork W2974402721 @default.
- W1557784023 hasRelatedWork W2999831276 @default.
- W1557784023 hasRelatedWork W3033935954 @default.
- W1557784023 hasRelatedWork W4280493527 @default.
- W1557784023 hasRelatedWork W4366262806 @default.
- W1557784023 hasRelatedWork W428523482 @default.
- W1557784023 hasVolume "188" @default.
- W1557784023 isParatext "false" @default.
- W1557784023 isRetracted "false" @default.
- W1557784023 magId "1557784023" @default.
- W1557784023 workType "article" @default.