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• W1557935087 endingPage "141" @default.
• W1557935087 startingPage "125" @default.
• W1557935087 abstract "Cells in the renal medulla are normally exposed to levels of NaCl that are extremely high and that vary with concentration of the urine. Such high levels of NaCl cause cellular perturbations, including increased DNA double-strand breaks, increased oxidation of DNA and proteins, and cytoskeletal alterations. Despite these perturbations the cells are able to survive and function because of osmoprotective responses that include accumulation of compatible organic osmolytes and increased abundance of heat shock proteins and water channels. Many of the responses are initiated by increased gene transcription, directed by the transcription factor TonEBP/OREBP. Here, we review the sensors of hypertonicity, the signaling pathways to TonEBP/OREBP, and the ways in which it is activated to increase transcription. Multiple signals are involved, including some that arise directly from the cellular perturbations caused by hypertonicity. Although the combination of these signals is necessary for full osmotic activation of TonEBP/OREBP, no one of them, alone, is sufficient. We conclude that hypertonicity profoundly alters the state of cells, providing numerous interrelated inputs to the osmoregulatory network." @default.
• W1557935087 created "2016-06-24" @default.
• W1557935087 creator A5025916093 @default.
• W1557935087 creator A5051074151 @default.
• W1557935087 date "2006-01-01" @default.
• W1557935087 modified "2023-09-27" @default.
• W1557935087 title "Tonicity-Dependent Regulation of Osmoprotective Genes in Mammalian Cells" @default.
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• W1557935087 doi "https://doi.org/10.1159/000096320" @default.
• W1557935087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17065809" @default.

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