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• W1558038422 startingPage "40" @default.
• W1558038422 abstract "Changes in extracellular space (ECS) diffusion parameters in astrogliotic tissue around a unilateral cortical stab wound were determined from concentration-time profiles of tetramethylammonium (TMA(+)) using TMA(+)-selective microelectrodes. Three diffusion parameters-ECS volume fraction alpha (alpha = ECS volume/ total tissue volume), tortuosity lambda (lambda(2) = D/ADC; where D is the free and ADC is the apparent diffusion coefficient of TMA(+) in the brain), and nonspecific TMA(+)uptake k'-were determined at 3, 7, 21, and 35 days postwounding (dpw), in the hemispheres ipsilateral and contralateral to the lesion. Following diffusion experiments, tissue sections were immunostained for glial fibrillary acidic protein (GFAP) and chondroitin-sulphate proteoglycans (CSPG). In the area 300-1000 micron around the wound, alpha was increased at 3, 7, and 21 dpw by about 20% but returned to control values at 35 dpw; lambda was increased at all four intervals, reaching a maximum at 7 dpw. k' was lower than in the contralateral hemisphere at 7, 21, and 35 dpw. Measurements 1,500-2,000 micron from the wound revealed only an increase in lambda at 7 dpw. The time course of changes in ECS diffusion parameters closely correlated with increased staining for GFAP and CSPG. Our results show that astrogliosis significantly changes the diffusion properties of nervous tissue, making it less permissive. Both hypertrophied astrocytic processes and an enhanced formation of some extracellular matrix molecules could affect, through changes in the diffusion of molecules in the ECS, neuron-glia communication, cross-talk between synapses, extrasynaptic transmission, and regenerative processes." @default.
• W1558038422 created "2016-06-24" @default.
• W1558038422 creator A5065203934 @default.
• W1558038422 creator A5069178308 @default.
• W1558038422 date "1999-10-01" @default.
• W1558038422 modified "2023-09-25" @default.
• W1558038422 title "Diffusion barriers evoked in the rat cortex by reactive astrogliosis" @default.
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• W1558038422 doi "https://doi.org/10.1002/(sici)1098-1136(199910)28:1<40::aid-glia5>3.0.co;2-6" @default.
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