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- W1558092960 abstract "The Colton system contains a single polymorphism, with relatively high and low incidence alleles represented by Coa (CO1) and Cob (CO2), respectively (Ala45Val). A third antigen, Co3, is present on all cells save those of the null phenotype, Co(a–b–). Absence of Co4 is associated with a Co(a–b–) Co:3 phenotype. The Colton antigens are located on aquaporin-1 (AQP1), a water channel-forming protein. The AQP1 gene is on chromosome 7p and the Co(a–b–) phenotype is sometimes associated with acquired chromosome 7 monosomy. Colton antibodies have caused severe HDFN and been implicated in acute and delayed haemolytic transfusion reactions." @default.
- W1558092960 created "2016-06-24" @default.
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- W1558092960 date "2013-01-28" @default.
- W1558092960 modified "2023-09-23" @default.
- W1558092960 title "Colton Blood Group System" @default.
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