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• W1558099492 abstract "Abstract We recently described γδ T cells alterations in patients with a cutaneous primary melanoma. To evaluate whether γδ T cells alterations persisted after melanoma removal, we performed a follow‐up study comparing the number and function of γδ T lymphocytes from 19 subjects, 4 years after the removal of a cutaneous primary melanoma, with the data obtained in the same subjects before the surgical intervention and with control donors. The number of circulating γδ + T cells after melanoma removal was not recovered to the levels found in controls. γδ + T cells producing TNF‐α or IFN‐γ were increased after melanoma removal in comparison with the same subjects before surgical intervention or with control donors. After in vitro culture, both the percentage and the expansion of γδ T cells were recovered to the values found in controls. In conclusion, the functional capacity of γδ T cells was in vitro recovered after melanoma removal, whereas their ex vivo number remained at lower levels than control donors." @default.
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• W1558099492 date "2010-07-06" @default.
• W1558099492 modified "2023-10-15" @default.
• W1558099492 title "Persistent Ex Vivo Low Number and Functional In Vitro Recovery of Circulating γδ T Cells after Removal of a Cutaneous Primary Melanoma" @default.
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• W1558099492 doi "https://doi.org/10.1111/j.1365-3083.2010.02413.x" @default.
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