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• W1558368577 endingPage "6345" @default.
• W1558368577 startingPage "6338" @default.
• W1558368577 abstract "Abstract NAIP CIIA HET-E and TP1 (NACHT) family proteins are involved in sensing intracellular pathogens or pathogen-derived molecules, triggering host defense responses resulting in caspase-mediated processing of proinflammatory cytokines and NF-κB activation. Caspase-associated recruitment domain, leucine-rich repeat, and NACHT-containing protein (CLAN), also known as ICE protease-activating factor, belongs to a branch of the NACHT family that contains proteins carrying caspase-associated recruitment domains (CARDs) and leucine-rich repeats (LRRs). By using gene transfer and RNA-interference approaches, we demonstrate in this study that CLAN modulates endogenous caspase-1 activation and subsequent IL-1β secretion from human macrophages after exposure to LPS, peptidoglycan, and pathogenic bacteria. CLAN was also found to mediate a direct antibacterial effect within macrophages after Salmonella infection and to sensitize host cells to Salmonella-induced cell death through a caspase-1-independent mechanism. These results indicate that CLAN contributes to several biological processes central to host defense, suggesting a prominent role for this NACHT family member in innate immunity." @default.
• W1558368577 created "2016-06-24" @default.
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• W1558368577 date "2004-11-15" @default.
• W1558368577 modified "2023-10-12" @default.
• W1558368577 title "Multiple Roles of CLAN (Caspase-Associated Recruitment Domain, Leucine-Rich Repeat, and NAIP CIIA HET-E, and TP1-Containing Protein) in the Mammalian Innate Immune Response" @default.
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• W1558368577 doi "https://doi.org/10.4049/jimmunol.173.10.6338" @default.
• W1558368577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15528373" @default.
• W1558368577 hasPublicationYear "2004" @default.
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