Matches in SemOpenAlex for { <https://semopenalex.org/work/W1558452949> ?p ?o ?g. }
- W1558452949 endingPage "1448" @default.
- W1558452949 startingPage "1437" @default.
- W1558452949 abstract "Sepsis is a complex, multifactorial, rapidly progressive disease characterized by an overwhelming activation of the immune system and the countervailing antiinflammatory response. In the current study in murine peritoneal macrophages, chlorogenic acid suppressed endotoxin-induced high mobility group box 1 (HMGB1) release in a concentration-dependent manner. Administration of chlorogenic acid also attenuated systemic HMGB1 accumulation in vivoand prevented mortality induced by endotoxemia and polymicrobial sepsis. The mechanisms of action of chlorogenic acid included attenuation of the increase in toll-like receptor (TLR)-4 expression and suppression of sepsis-induced signaling pathways, such as c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB, which are critical for cytokine release. The protection conferred by chlorogenic acid was achieved through modulation of cytokine and chemokine release, suppression of immune cell apoptosis and augmentation of bacterial elimination. Chlorogenic acid warrants further evaluation as a potential therapeutic agent for the treatment of sepsis and other potentially fatal systemic inflammatory disorders." @default.
- W1558452949 created "2016-06-24" @default.
- W1558452949 creator A5059462369 @default.
- W1558452949 creator A5088988274 @default.
- W1558452949 creator A5091003200 @default.
- W1558452949 date "2012-11-01" @default.
- W1558452949 modified "2023-10-17" @default.
- W1558452949 title "Chlorogenic Acid Attenuates High Mobility Group Box 1 (HMGB1) and Enhances Host Defense Mechanisms in Murine Sepsis" @default.
- W1558452949 cites W1540820582 @default.
- W1558452949 cites W1545479773 @default.
- W1558452949 cites W1566540765 @default.
- W1558452949 cites W1592616574 @default.
- W1558452949 cites W1614633287 @default.
- W1558452949 cites W1890847758 @default.
- W1558452949 cites W1939928889 @default.
- W1558452949 cites W1967774301 @default.
- W1558452949 cites W1973404097 @default.
- W1558452949 cites W1977905350 @default.
- W1558452949 cites W1981243375 @default.
- W1558452949 cites W1983379130 @default.
- W1558452949 cites W1987993459 @default.
- W1558452949 cites W2003589653 @default.
- W1558452949 cites W2004266769 @default.
- W1558452949 cites W2004465286 @default.
- W1558452949 cites W2006200448 @default.
- W1558452949 cites W2006660114 @default.
- W1558452949 cites W2008693724 @default.
- W1558452949 cites W2016612907 @default.
- W1558452949 cites W2021308604 @default.
- W1558452949 cites W2021736304 @default.
- W1558452949 cites W2023945291 @default.
- W1558452949 cites W2031501484 @default.
- W1558452949 cites W2031920769 @default.
- W1558452949 cites W2040567177 @default.
- W1558452949 cites W2041269288 @default.
- W1558452949 cites W2043034601 @default.
- W1558452949 cites W2053721185 @default.
- W1558452949 cites W2059217150 @default.
- W1558452949 cites W2060371040 @default.
- W1558452949 cites W2061163173 @default.
- W1558452949 cites W2065553623 @default.
- W1558452949 cites W2088712525 @default.
- W1558452949 cites W2104465828 @default.
- W1558452949 cites W2104765191 @default.
- W1558452949 cites W2104776505 @default.
- W1558452949 cites W2114861800 @default.
- W1558452949 cites W2126648878 @default.
- W1558452949 cites W2147921405 @default.
- W1558452949 cites W2160369507 @default.
- W1558452949 cites W2164714222 @default.
- W1558452949 cites W2329822565 @default.
- W1558452949 cites W2783888699 @default.
- W1558452949 cites W4243836839 @default.
- W1558452949 cites W4245868295 @default.
- W1558452949 cites W4294216491 @default.
- W1558452949 doi "https://doi.org/10.2119/molmed.2012.00279" @default.
- W1558452949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3563707" @default.
- W1558452949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23168580" @default.
- W1558452949 hasPublicationYear "2012" @default.
- W1558452949 type Work @default.
- W1558452949 sameAs 1558452949 @default.
- W1558452949 citedByCount "45" @default.
- W1558452949 countsByYear W15584529492013 @default.
- W1558452949 countsByYear W15584529492014 @default.
- W1558452949 countsByYear W15584529492015 @default.
- W1558452949 countsByYear W15584529492016 @default.
- W1558452949 countsByYear W15584529492017 @default.
- W1558452949 countsByYear W15584529492018 @default.
- W1558452949 countsByYear W15584529492019 @default.
- W1558452949 countsByYear W15584529492020 @default.
- W1558452949 countsByYear W15584529492021 @default.
- W1558452949 countsByYear W15584529492023 @default.
- W1558452949 crossrefType "journal-article" @default.
- W1558452949 hasAuthorship W1558452949A5059462369 @default.
- W1558452949 hasAuthorship W1558452949A5088988274 @default.
- W1558452949 hasAuthorship W1558452949A5091003200 @default.
- W1558452949 hasBestOaLocation W15584529491 @default.
- W1558452949 hasConcept C13373296 @default.
- W1558452949 hasConcept C184235292 @default.
- W1558452949 hasConcept C185592680 @default.
- W1558452949 hasConcept C203014093 @default.
- W1558452949 hasConcept C2776914184 @default.
- W1558452949 hasConcept C2778384902 @default.
- W1558452949 hasConcept C2778690821 @default.
- W1558452949 hasConcept C2780117898 @default.
- W1558452949 hasConcept C2780545709 @default.
- W1558452949 hasConcept C31903555 @default.
- W1558452949 hasConcept C51551487 @default.
- W1558452949 hasConcept C71924100 @default.
- W1558452949 hasConcept C86803240 @default.
- W1558452949 hasConcept C8891405 @default.
- W1558452949 hasConcept C95444343 @default.
- W1558452949 hasConcept C97029542 @default.
- W1558452949 hasConcept C98274493 @default.
- W1558452949 hasConceptScore W1558452949C13373296 @default.
- W1558452949 hasConceptScore W1558452949C184235292 @default.
- W1558452949 hasConceptScore W1558452949C185592680 @default.
- W1558452949 hasConceptScore W1558452949C203014093 @default.