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- W1558470115 endingPage "81" @default.
- W1558470115 startingPage "39" @default.
- W1558470115 abstract "Proteins that fail to fold properly as well as constitutive or regulated short-lived proteins of the endoplasmatic reticulum (ER) are subjected to proteolysis by cytosolic 26 S proteasomes. This process, termed ER-associated protein degradation (ERAD), has also been implicated in the generation of some important human disorders, for example, cystic fibrosis. To become accessible to the proteasome, ERAD substrates must first be retrogradely transported from the ER into the cytosol, in a process termed dislocation. Surprisingly, protein dislocation from the ER seems to require at least some components that also mediate import into this compartment. Moreover, polyubiquitination of ERAD substrates at the ER membrane as well as the cytoplasmic Cdc48p/Np14p/Ufd1p complex were shown to contribute to this export reaction. In this article we will summarize our current knowledge on ERAD and discuss the possible function of certain components involved in this process." @default.
- W1558470115 created "2016-06-24" @default.
- W1558470115 creator A5001922195 @default.
- W1558470115 creator A5010355607 @default.
- W1558470115 creator A5036147408 @default.
- W1558470115 date "2002-01-01" @default.
- W1558470115 modified "2023-10-18" @default.
- W1558470115 title "Endoplasmic reticulum-associated protein degradation" @default.
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