FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1558478817> ?p ?o ?g. }

• W1558478817 endingPage "8" @default.
• W1558478817 startingPage "5341" @default.
• W1558478817 abstract "Replicative senescence is characterized by irreversible growth arrest and has been defined by four genetic complementation groups. One of these groups is associated with the predominance of underphosphorylated, growth-suppressive retinoblastoma tumor suppressor protein (pRb). Although certain members of the cyclin-dependent kinase (cdk)/cyclin family, some of which phosphorylate pRb, are underexpressed in senescent cells, others are expressed but inactive. This lack of cdk activity and arrest in the G1 phase of the cell cycle is likely attributable to the induction upon senescence of the G1-S cdk/cyclin inhibitors p21 (WAF1/CIP1/Sdi) and p16INK4. In fact, in early presenescent normal diploid fibroblasts in which p21 is inactivated, senescence is bypassed or postponed. Moreover, in senescent cells in which p53 function was inhibited, DNA synthesis was reinitiated, an effect likely attributable, in part, to the dependence of p21 expression on p53. We report here that the apparent inactivation of p21 in senescent human fibroblasts through the introduction of inhibitory alpha-p21 antibodies causes these cells to reenter the S-phase of the cell cycle. The disruption of p21 activity affects the p21-Rb-E2F pathway in that the expression of genes transcriptionally regulated by E2F, such as cyclin A and cdc2, were found to be up-regulated in injected cells. No evidence of cell division was observed. This suggests that p21 plays an important role in the maintenance of senescence and in the inhibition of S-phase progression, but inhibition of p21 activity is insufficient to permit cells to complete the cell cycle." @default.
• W1558478817 created "2016-06-24" @default.
• W1558478817 creator A5008951143 @default.
• W1558478817 creator A5017196029 @default.
• W1558478817 creator A5021395786 @default.
• W1558478817 creator A5035119222 @default.
• W1558478817 creator A5044450151 @default.
• W1558478817 creator A5055167302 @default.
• W1558478817 date "1999-10-15" @default.
• W1558478817 modified "2023-09-27" @default.
• W1558478817 title "Microinjection of anti-p21 antibodies induces senescent Hs68 human fibroblasts to synthesize DNA but not to divide." @default.
• W1558478817 cites W1500532974 @default.
• W1558478817 cites W1507169382 @default.
• W1558478817 cites W1514540426 @default.
• W1558478817 cites W1878636505 @default.
• W1558478817 cites W1974654016 @default.
• W1558478817 cites W1978245541 @default.
• W1558478817 cites W1979669293 @default.
• W1558478817 cites W1982622947 @default.
• W1558478817 cites W1988762859 @default.
• W1558478817 cites W1991477412 @default.
• W1558478817 cites W1992934869 @default.
• W1558478817 cites W1999330214 @default.
• W1558478817 cites W2003282728 @default.
• W1558478817 cites W2004314923 @default.
• W1558478817 cites W2007772649 @default.
• W1558478817 cites W2012293213 @default.
• W1558478817 cites W2015519364 @default.
• W1558478817 cites W2015737860 @default.
• W1558478817 cites W2018850085 @default.
• W1558478817 cites W2029816972 @default.
• W1558478817 cites W2032428064 @default.
• W1558478817 cites W2035443068 @default.
• W1558478817 cites W2036385196 @default.
• W1558478817 cites W2046590643 @default.
• W1558478817 cites W2050551830 @default.
• W1558478817 cites W2052787638 @default.
• W1558478817 cites W2054548947 @default.
• W1558478817 cites W2055247766 @default.
• W1558478817 cites W2056025078 @default.
• W1558478817 cites W2057628471 @default.
• W1558478817 cites W2065187379 @default.
• W1558478817 cites W2081290278 @default.
• W1558478817 cites W2085797277 @default.
• W1558478817 cites W2087404852 @default.
• W1558478817 cites W2089218510 @default.
• W1558478817 cites W2103981303 @default.
• W1558478817 cites W2104908670 @default.
• W1558478817 cites W2105902888 @default.
• W1558478817 cites W2115982441 @default.
• W1558478817 cites W2116283918 @default.
• W1558478817 cites W2116529873 @default.
• W1558478817 cites W2119581810 @default.
• W1558478817 cites W2123292462 @default.
• W1558478817 cites W2125453837 @default.
• W1558478817 cites W2130193486 @default.
• W1558478817 cites W2134331780 @default.
• W1558478817 cites W2154421489 @default.
• W1558478817 cites W2155657755 @default.
• W1558478817 cites W2157033538 @default.
• W1558478817 cites W2162461992 @default.
• W1558478817 cites W2162797616 @default.
• W1558478817 cites W2163386603 @default.
• W1558478817 cites W2347113937 @default.
• W1558478817 cites W2411706228 @default.
• W1558478817 cites W2414565884 @default.
• W1558478817 cites W2764381286 @default.
• W1558478817 cites W34204517 @default.
• W1558478817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10537318" @default.
• W1558478817 hasPublicationYear "1999" @default.
• W1558478817 type Work @default.
• W1558478817 sameAs 1558478817 @default.
• W1558478817 citedByCount "5" @default.
• W1558478817 countsByYear W15584788172016 @default.
• W1558478817 countsByYear W15584788172018 @default.
• W1558478817 countsByYear W15584788172021 @default.
• W1558478817 countsByYear W15584788172023 @default.
• W1558478817 crossrefType "journal-article" @default.
• W1558478817 hasAuthorship W1558478817A5008951143 @default.
• W1558478817 hasAuthorship W1558478817A5017196029 @default.
• W1558478817 hasAuthorship W1558478817A5021395786 @default.
• W1558478817 hasAuthorship W1558478817A5035119222 @default.
• W1558478817 hasAuthorship W1558478817A5044450151 @default.
• W1558478817 hasAuthorship W1558478817A5055167302 @default.
• W1558478817 hasConcept C105696609 @default.
• W1558478817 hasConcept C11882975 @default.
• W1558478817 hasConcept C120089663 @default.
• W1558478817 hasConcept C120504264 @default.
• W1558478817 hasConcept C124320809 @default.
• W1558478817 hasConcept C143425029 @default.
• W1558478817 hasConcept C1491633281 @default.
• W1558478817 hasConcept C153911025 @default.
• W1558478817 hasConcept C16438837 @default.
• W1558478817 hasConcept C184235292 @default.
• W1558478817 hasConcept C2776062698 @default.
• W1558478817 hasConcept C2778298596 @default.
• W1558478817 hasConcept C29537977 @default.
• W1558478817 hasConcept C522857546 @default.

• next