FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1558515329> ?p ?o ?g. }

• W1558515329 endingPage "64" @default.
• W1558515329 startingPage "655" @default.
• W1558515329 abstract "The overexpression of manganese superoxide dismutase (MnSOD), an enzyme that catalyzes the removal of superoxide (O2*-) from the mitochondria, has been shown to be closely associated with tumor regression in vivo and loss of the malignant phenotype in vitro. To investigate the mechanism by which MnSOD overexpression mediates this reversal, we have established 29 independent, clonal MnSOD-overexpressing HT-1080 fibrosarcoma cells. MnSOD activity is inversely correlated with cell proliferation in our cell lines. Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition. Confocal laser microscopy was used in combination with the oxidant-sensitive fluorescent dyes dihydrorhodamine-123, dihydroethidium, and 2',7'-dichlorodihydrofluorescein diacetate to determine the oxidizing capacity of the MnSOD-overexpressing cells. When compared with parental or control cell lines, there was a significant decrease in the rate of oxidation of the fluorophores in the MnSOD-overexpressing cell lines. Thus, an increase in the oxidizing capacity of the cells does not appear to mediate the inhibition of proliferation associated with MnSOD overexpression. Superoxide dismutase has also been shown to enhance the cytotoxic activity of NO* toward tumor cells. In this study, we have shown that MnSOD overexpression enhances the cytostatic action of the NO* donors, sodium nitroprusside, 3-morpholinosydnonomine, and (Z)-1-[2-aminethyl)-N-(2-ammonioethyl)amino]diazen-1-+ ++ium-1,2-diolate in a dose-dependent manner. In addition, the NO* toxicity is blocked by oxyhemoglobin, a NO* scavenger. Our findings suggest that NO* may play a role in the reversal of tumorigenicity associated with MnSOD overexpression." @default.
• W1558515329 created "2016-06-24" @default.
• W1558515329 creator A5028329841 @default.
• W1558515329 creator A5043743871 @default.
• W1558515329 creator A5053775314 @default.
• W1558515329 creator A5067471566 @default.
• W1558515329 creator A5084767307 @default.
• W1558515329 date "1999-09-01" @default.
• W1558515329 modified "2023-09-23" @default.
• W1558515329 title "Nitric oxide enhances the manganese superoxide dismutase-dependent suppression of proliferation in HT-1080 fibrosarcoma cells." @default.
• W1558515329 cites W1027091479 @default.
• W1558515329 cites W1500954499 @default.
• W1558515329 cites W1509091993 @default.
• W1558515329 cites W1544209968 @default.
• W1558515329 cites W1546267534 @default.
• W1558515329 cites W1813230101 @default.
• W1558515329 cites W1821918060 @default.
• W1558515329 cites W1834041853 @default.
• W1558515329 cites W1940436875 @default.
• W1558515329 cites W1971827510 @default.
• W1558515329 cites W1981783025 @default.
• W1558515329 cites W1982249395 @default.
• W1558515329 cites W1983338479 @default.
• W1558515329 cites W1991608880 @default.
• W1558515329 cites W1994303699 @default.
• W1558515329 cites W1995191054 @default.
• W1558515329 cites W2008577285 @default.
• W1558515329 cites W2008680254 @default.
• W1558515329 cites W2017554945 @default.
• W1558515329 cites W2018205667 @default.
• W1558515329 cites W2019343963 @default.
• W1558515329 cites W2019601413 @default.
• W1558515329 cites W2030496404 @default.
• W1558515329 cites W2034667862 @default.
• W1558515329 cites W2041657908 @default.
• W1558515329 cites W2043285281 @default.
• W1558515329 cites W2048243713 @default.
• W1558515329 cites W2049140233 @default.
• W1558515329 cites W2051867686 @default.
• W1558515329 cites W2053322737 @default.
• W1558515329 cites W2056168344 @default.
• W1558515329 cites W2057022763 @default.
• W1558515329 cites W2062195767 @default.
• W1558515329 cites W2063573861 @default.
• W1558515329 cites W2063802411 @default.
• W1558515329 cites W2069333165 @default.
• W1558515329 cites W2070712167 @default.
• W1558515329 cites W2073159120 @default.
• W1558515329 cites W2081595932 @default.
• W1558515329 cites W2085821822 @default.
• W1558515329 cites W2089976585 @default.
• W1558515329 cites W2092721077 @default.
• W1558515329 cites W2094090874 @default.
• W1558515329 cites W2094539803 @default.
• W1558515329 cites W2095888973 @default.
• W1558515329 cites W2101422765 @default.
• W1558515329 cites W2101782082 @default.
• W1558515329 cites W2108028781 @default.
• W1558515329 cites W2109717482 @default.
• W1558515329 cites W2109922742 @default.
• W1558515329 cites W2111732338 @default.
• W1558515329 cites W2121774612 @default.
• W1558515329 cites W2157548891 @default.
• W1558515329 cites W2170051746 @default.
• W1558515329 cites W2188751783 @default.
• W1558515329 cites W2223649658 @default.
• W1558515329 cites W2319302105 @default.
• W1558515329 cites W2340179534 @default.
• W1558515329 cites W2340892831 @default.
• W1558515329 cites W2395675726 @default.
• W1558515329 cites W2464429470 @default.
• W1558515329 cites W2475137391 @default.
• W1558515329 cites W302347924 @default.
• W1558515329 cites W625127082 @default.
• W1558515329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10511315" @default.
• W1558515329 hasPublicationYear "1999" @default.
• W1558515329 type Work @default.
• W1558515329 sameAs 1558515329 @default.
• W1558515329 citedByCount "4" @default.
• W1558515329 countsByYear W15585153292013 @default.
• W1558515329 crossrefType "journal-article" @default.
• W1558515329 hasAuthorship W1558515329A5028329841 @default.
• W1558515329 hasAuthorship W1558515329A5043743871 @default.
• W1558515329 hasAuthorship W1558515329A5053775314 @default.
• W1558515329 hasAuthorship W1558515329A5067471566 @default.
• W1558515329 hasAuthorship W1558515329A5084767307 @default.
• W1558515329 hasConcept C134018914 @default.
• W1558515329 hasConcept C153911025 @default.
• W1558515329 hasConcept C181199279 @default.
• W1558515329 hasConcept C2775838275 @default.
• W1558515329 hasConcept C2776495794 @default.
• W1558515329 hasConcept C2780795997 @default.
• W1558515329 hasConcept C48349386 @default.
• W1558515329 hasConcept C519581460 @default.
• W1558515329 hasConcept C54355233 @default.
• W1558515329 hasConcept C55493867 @default.
• W1558515329 hasConcept C62112901 @default.
• W1558515329 hasConcept C81885089 @default.

• next