FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1558522890> ?p ?o ?g. }

• W1558522890 endingPage "2634" @default.
• W1558522890 startingPage "2629" @default.
• W1558522890 abstract "We have examined the kinetics of the inhibition of human immunodeficiency virus type 1 (HIV-1) particle infectivity by protease inhibitors (PIs) in cell culture, using either transfected HeLa cells or infected peripheral blood mononuclear cells (PBMCs) as producers of infectious virions. Both the kinetics of the initiation of antiviral activity after addition of the PIs to these cultures and the kinetics of restoration of virion infectivity after removal of the PIs from the treated cultures were examined. We found that the kinetics of initiation of particle infectivity inhibition produced by a high extracellular concentration (5 microM) of the inhibitors were similar for all five inhibitors tested: loss of particle infectivity was perceptible as early as 1 h after the initiation of PI treatment and increased gradually thereafter. By contrast, the durability of this antiviral effect following removal of the drug from the culture varied dramatically according to the drug studied. In transfected HeLa cells, saquinavir and nelfinavir exerted the most prolonged inhibition, with the half-lives of their antiviral activities being greater than 24 h, while ritonavir exerted an intermediate length of inhibition (18 h) and indinavir and amprenavir exerted a reproducibly shorter length of inhibition (5 h). For all five tested PIs, these kinetics were significantly faster in PBMCs than in HeLa cells. The striking differences in antiviral kinetics observed among the different PIs appear mostly due to differences in their intracellular concentrations and/or rates of cellular clearance. Our observations, although limited to tissue culture conditions, may help delineate the cellular parameters of the antiviral activities of HIV-1 PIs and further optimize the efficiencies of these antiretrovirals in vivo." @default.
• W1558522890 created "2016-06-24" @default.
• W1558522890 creator A5016433071 @default.
• W1558522890 creator A5061527531 @default.
• W1558522890 creator A5071030872 @default.
• W1558522890 creator A5079141870 @default.
• W1558522890 creator A5087326971 @default.
• W1558522890 date "1999-11-01" @default.
• W1558522890 modified "2023-10-16" @default.
• W1558522890 title "Kinetics of Antiviral Activity and Intracellular Pharmacokinetics of Human Immunodeficiency Virus Type 1 Protease Inhibitors in Tissue Culture" @default.
• W1558522890 cites W1586873018 @default.
• W1558522890 cites W1606975204 @default.
• W1558522890 cites W1659719610 @default.
• W1558522890 cites W1684659302 @default.
• W1558522890 cites W1982448824 @default.
• W1558522890 cites W1998575185 @default.
• W1558522890 cites W2014970708 @default.
• W1558522890 cites W2025152688 @default.
• W1558522890 cites W2039862437 @default.
• W1558522890 cites W2041929607 @default.
• W1558522890 cites W2042153403 @default.
• W1558522890 cites W2058396264 @default.
• W1558522890 cites W206917024 @default.
• W1558522890 cites W2069366448 @default.
• W1558522890 cites W2088787526 @default.
• W1558522890 cites W2089329334 @default.
• W1558522890 cites W2106621801 @default.
• W1558522890 cites W2107791948 @default.
• W1558522890 cites W2114742412 @default.
• W1558522890 cites W2124219170 @default.
• W1558522890 cites W2130082288 @default.
• W1558522890 cites W2149129111 @default.
• W1558522890 cites W2149568397 @default.
• W1558522890 cites W2154638204 @default.
• W1558522890 cites W2155706932 @default.
• W1558522890 cites W2315609346 @default.
• W1558522890 cites W2329393410 @default.
• W1558522890 cites W4235712548 @default.
• W1558522890 cites W4251307042 @default.
• W1558522890 cites W4294293047 @default.
• W1558522890 cites W44345625 @default.
• W1558522890 doi "https://doi.org/10.1128/aac.43.11.2629" @default.
• W1558522890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/89535" @default.
• W1558522890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10543739" @default.
• W1558522890 hasPublicationYear "1999" @default.
• W1558522890 type Work @default.
• W1558522890 sameAs 1558522890 @default.
• W1558522890 citedByCount "58" @default.
• W1558522890 countsByYear W15585228902012 @default.
• W1558522890 countsByYear W15585228902014 @default.
• W1558522890 countsByYear W15585228902017 @default.
• W1558522890 crossrefType "journal-article" @default.
• W1558522890 hasAuthorship W1558522890A5016433071 @default.
• W1558522890 hasAuthorship W1558522890A5061527531 @default.
• W1558522890 hasAuthorship W1558522890A5071030872 @default.
• W1558522890 hasAuthorship W1558522890A5079141870 @default.
• W1558522890 hasAuthorship W1558522890A5087326971 @default.
• W1558522890 hasBestOaLocation W15585228901 @default.
• W1558522890 hasConcept C106358424 @default.
• W1558522890 hasConcept C137061746 @default.
• W1558522890 hasConcept C142462285 @default.
• W1558522890 hasConcept C153911025 @default.
• W1558522890 hasConcept C159047783 @default.
• W1558522890 hasConcept C181199279 @default.
• W1558522890 hasConcept C202751555 @default.
• W1558522890 hasConcept C2522874641 @default.
• W1558522890 hasConcept C2776714187 @default.
• W1558522890 hasConcept C2776937687 @default.
• W1558522890 hasConcept C2777210460 @default.
• W1558522890 hasConcept C2777363262 @default.
• W1558522890 hasConcept C2777366897 @default.
• W1558522890 hasConcept C2777583353 @default.
• W1558522890 hasConcept C2779298103 @default.
• W1558522890 hasConcept C28406088 @default.
• W1558522890 hasConcept C2993143319 @default.
• W1558522890 hasConcept C54355233 @default.
• W1558522890 hasConcept C55493867 @default.
• W1558522890 hasConcept C79879829 @default.
• W1558522890 hasConcept C81885089 @default.
• W1558522890 hasConcept C86803240 @default.
• W1558522890 hasConceptScore W1558522890C106358424 @default.
• W1558522890 hasConceptScore W1558522890C137061746 @default.
• W1558522890 hasConceptScore W1558522890C142462285 @default.
• W1558522890 hasConceptScore W1558522890C153911025 @default.
• W1558522890 hasConceptScore W1558522890C159047783 @default.
• W1558522890 hasConceptScore W1558522890C181199279 @default.
• W1558522890 hasConceptScore W1558522890C202751555 @default.
• W1558522890 hasConceptScore W1558522890C2522874641 @default.
• W1558522890 hasConceptScore W1558522890C2776714187 @default.
• W1558522890 hasConceptScore W1558522890C2776937687 @default.
• W1558522890 hasConceptScore W1558522890C2777210460 @default.
• W1558522890 hasConceptScore W1558522890C2777363262 @default.
• W1558522890 hasConceptScore W1558522890C2777366897 @default.
• W1558522890 hasConceptScore W1558522890C2777583353 @default.
• W1558522890 hasConceptScore W1558522890C2779298103 @default.
• W1558522890 hasConceptScore W1558522890C28406088 @default.
• W1558522890 hasConceptScore W1558522890C2993143319 @default.
• W1558522890 hasConceptScore W1558522890C54355233 @default.

• next