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- W1558528060 abstract "Diet affects nearly every aspect of animal life such as development, metabolism, behavior, and aging, both directly by supplying nutrients and indirectly through gut microbiota. C. elegans feeds on bacteria, and like other animals, different bacterial diets induce distinct dietary responses in the worm. However, the lack of certain critical tools hampers the use of worms as a model for dietary signaling. Here, we genetically engineered the bacterial strain OP50, the standard laboratory diet for C. elegans, making it compatible for dsRNA production and delivery. Using this RNAi-compatible OP50 strain and the other bacterial strain HT115, we feed worms different diets while delivering RNAi to interrogate the genetic basis underlying diet-dependent differential modulation of development, metabolism, behavior, and aging. We show by RNAi that neuroendocrine and mTOR pathways are involved in mediating differential dietary responses. This genetic tool greatly facilitates the use of C. elegans as a model for dietary signaling." @default.
- W1558528060 created "2016-06-24" @default.
- W1558528060 creator A5008927356 @default.
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- W1558528060 date "2015-05-01" @default.
- W1558528060 modified "2023-10-15" @default.
- W1558528060 title "RNAi Interrogation of Dietary Modulation of Development, Metabolism, Behavior, and Aging in C. elegans" @default.
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- W1558528060 doi "https://doi.org/10.1016/j.celrep.2015.04.024" @default.
- W1558528060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4439342" @default.
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