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- W1558664881 abstract "Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and a highly malignant cancer associated with poor prognosis and low overall survival. Here, we describe a role of DRAK1 (DAP kinase-related apoptosis-inducing kinase 1) in head and neck cancer cells. DRAK1 is significantly overexpressed in primary head and neck tumors and cell lines. Overexpression of DRAK1 decreased the TGF-β1-induced transcriptional activity and expression of tumor suppressor target genes, including p15, p21, whereas DRAK1 silencing enhanced. Furthermore, endogenous depletion of DRAK1 enhanced the TGF-β1-induced cell growth inhibition and suppressed the tumorigenic ability of head and neck cancer cells in vivo. Interestingly, the gain- or loss-of-function of DRAK1 did not change the TGF-β1-induced phosphorylation of Smad2/3. DRAK1 specifically binds to Smad3 through its kinase domain, thereby blocking recruitment of Smad4 and translocation of Smad3 into nucleus. Thus, our findings suggest that aberrant expression of DRAK1 increases tumorigenic potential through the inhibition of TGF-β1 tumor suppressor activity in head and neck cancer cells. *This work was supported by a National Research Foundation grant of Korea (2009-0081756) funded by the Korea government. Citation Format: Kyung-Min Yang, WonJoo Kim, Jeong-Mi Lee, Seong-Jin Kim. DRAK1 overexpressed in head and neck cancer suppresses the TGF-β1 tumor suppressor activity in head and neck cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4411. doi:10.1158/1538-7445.AM2014-4411" @default.
- W1558664881 created "2016-06-24" @default.
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- W1558664881 date "2014-09-30" @default.
- W1558664881 modified "2023-09-26" @default.
- W1558664881 title "Abstract 4411: DRAK1 overexpressed in head and neck cancer suppresses the TGF-β1 tumor suppressor activity in head and neck cancer cells" @default.
- W1558664881 doi "https://doi.org/10.1158/1538-7445.am2014-4411" @default.
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