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- W1558719145 abstract "This chapter describes the production, purification, and assay of streptolysin O (SLO). Two hemolytic and cytolytic toxins, SLO and streptolysin S (SLS), are produced by group A streptococci. SLO is a 60-kDa immunogenic protein released in conventional culture media throughout the exponential phase of growth. In contrast, SLS is a less well-understood, nonimmunogenic toxin that is never detected unless a carrier (also called inducer) is added to the culture or to resting cell suspensions. Many chemically unrelated inducers are reported, the most potent being the RNase-resistant fraction of yeast RNA (RNA core) and lipoteichoic acids. The hemolytic activity can be transferred from one inducer to another. SLS is a very potent membrane-damaging agent. It lyses a wide variety of living cells. Its lytic spectrum is somewhat broader than SLO; it is lytic or cytotoxic not only for eukaryotic cells but also for wall-less forms of some bacteria, notably protoplasts and L forms from various species." @default.
- W1558719145 created "2016-06-24" @default.
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- W1558719145 date "1988-01-01" @default.
- W1558719145 modified "2023-10-18" @default.
- W1558719145 title "[9] Production, purification, and assay of streptolysin S" @default.
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- W1558719145 doi "https://doi.org/10.1016/s0076-6879(88)65012-9" @default.
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