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- W1558856110 endingPage "CMT.S1161" @default.
- W1558856110 startingPage "CMT.S1161" @default.
- W1558856110 abstract "Treatment for hepatitis B (HBV), a global disease affecting over 400 million persons, has changed over the past 15 years. Many of the current treatments are oral therapies which suppress HBV viral load and improve liver-related outcomes. However, differences exist in the currently available therapies both in terms of potency and resistance. The newest HBV nucleotide to be approved for the treatment of hepatitis B is tenofovir disoproxil fumarate that when phosphorylated to its active form leads to DNA chain termination. Tenofovir is active against human immunodeficiency virus (HIV) and was approved for its treatment in 2001. It is also active against HBV and was approved for its treatment in 2008. Tenofovir has emerged as an effective and potent therapy against lamivudine resistant strains as well as wild type HBV. Tenofovir resistance to HBV is rare. Long-term use of tenofovir has been associated with renal and bone marrow toxicity in some HIV-infected patients. To date, this is the only oral therapy which is both potent and does not lead to viral resistance in both treatment naïve and experienced patients. Further studies in HBV mono-infected persons are needed to evaluate long-term impact of tenofovir use." @default.
- W1558856110 created "2016-06-24" @default.
- W1558856110 creator A5030626829 @default.
- W1558856110 creator A5035810000 @default.
- W1558856110 creator A5061768512 @default.
- W1558856110 date "2009-01-01" @default.
- W1558856110 modified "2023-09-25" @default.
- W1558856110 title "Pharmacotherapy of Chronic Hepatitis B in Adults: Focus on Tenofovir Disoproxil Fumarate" @default.
- W1558856110 cites W125934661 @default.
- W1558856110 cites W1653182164 @default.
- W1558856110 cites W1796434206 @default.
- W1558856110 cites W1964039671 @default.
- W1558856110 cites W1966772739 @default.
- W1558856110 cites W1968434521 @default.
- W1558856110 cites W1968603686 @default.
- W1558856110 cites W1968789632 @default.
- W1558856110 cites W1973933851 @default.
- W1558856110 cites W1973982611 @default.
- W1558856110 cites W1977072157 @default.
- W1558856110 cites W1979223173 @default.
- W1558856110 cites W1982416677 @default.
- W1558856110 cites W1982960788 @default.
- W1558856110 cites W1985860298 @default.
- W1558856110 cites W1989065888 @default.
- W1558856110 cites W1993605600 @default.
- W1558856110 cites W1999635905 @default.
- W1558856110 cites W2004567313 @default.
- W1558856110 cites W2005192912 @default.
- W1558856110 cites W2007666753 @default.
- W1558856110 cites W2008517556 @default.
- W1558856110 cites W2011397954 @default.
- W1558856110 cites W2014097029 @default.
- W1558856110 cites W2014500655 @default.
- W1558856110 cites W2021973864 @default.
- W1558856110 cites W2022552811 @default.
- W1558856110 cites W2023850401 @default.
- W1558856110 cites W2027543203 @default.
- W1558856110 cites W2029914836 @default.
- W1558856110 cites W2033963850 @default.
- W1558856110 cites W2039218050 @default.
- W1558856110 cites W2040820236 @default.
- W1558856110 cites W2041839109 @default.
- W1558856110 cites W2045823177 @default.
- W1558856110 cites W2046924643 @default.
- W1558856110 cites W2049620975 @default.
- W1558856110 cites W2053638799 @default.
- W1558856110 cites W2055483238 @default.
- W1558856110 cites W2055818289 @default.
- W1558856110 cites W2056779298 @default.
- W1558856110 cites W2058388169 @default.
- W1558856110 cites W2059560167 @default.
- W1558856110 cites W2060138851 @default.
- W1558856110 cites W2069992406 @default.
- W1558856110 cites W2070341160 @default.
- W1558856110 cites W2077704646 @default.
- W1558856110 cites W2077844977 @default.
- W1558856110 cites W2080972647 @default.
- W1558856110 cites W2081469615 @default.
- W1558856110 cites W2084004754 @default.
- W1558856110 cites W2089274167 @default.
- W1558856110 cites W2089440001 @default.
- W1558856110 cites W2089528742 @default.
- W1558856110 cites W2091287215 @default.
- W1558856110 cites W2091989309 @default.
- W1558856110 cites W2094608386 @default.
- W1558856110 cites W2095444472 @default.
- W1558856110 cites W2095500893 @default.
- W1558856110 cites W2099690830 @default.
- W1558856110 cites W2102245402 @default.
- W1558856110 cites W2102758806 @default.
- W1558856110 cites W2104450067 @default.
- W1558856110 cites W2108147025 @default.
- W1558856110 cites W2111704741 @default.
- W1558856110 cites W2114392718 @default.
- W1558856110 cites W2114922466 @default.
- W1558856110 cites W2120667564 @default.
- W1558856110 cites W2122749974 @default.
- W1558856110 cites W2128323185 @default.
- W1558856110 cites W2134595040 @default.
- W1558856110 cites W2136425954 @default.
- W1558856110 cites W2138912664 @default.
- W1558856110 cites W2142285241 @default.
- W1558856110 cites W2150966027 @default.
- W1558856110 cites W2151425917 @default.
- W1558856110 cites W2154488194 @default.
- W1558856110 cites W2155000149 @default.
- W1558856110 cites W2161280033 @default.
- W1558856110 cites W2168745648 @default.
- W1558856110 cites W2170164020 @default.
- W1558856110 cites W2293495463 @default.
- W1558856110 cites W2317069692 @default.
- W1558856110 cites W2319441763 @default.
- W1558856110 cites W2323719395 @default.
- W1558856110 cites W2338794667 @default.
- W1558856110 cites W2393327590 @default.
- W1558856110 cites W2431972701 @default.
- W1558856110 cites W45130134 @default.
- W1558856110 cites W51140721 @default.