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- W1558902404 abstract "Hookworm is considered a neglected tropical disease, which is a group of parasitic and related infectious diseases that are common infections in low-income countries, where they produce a disease burden equivalent to HIV/AIDS or malaria. Despite their importance, progress on developing vaccines for neglected tropical diseases such as hookworm has lagged because of critical technical hurdles. These include the lack of relevant animal models for efficacy testing, an absence of correlates of protection in humans, and minimal experience in the development technologies to bring these vaccines to the clinic. Herein, we review the current status of a vaccine against an important NTD the human hookworm, Necator americanus, as a cautionary tale of hurdles for the preclinical development of vaccines for this important group of diseases." @default.
- W1558902404 created "2016-06-24" @default.
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- W1558902404 date "2012-07-18" @default.
- W1558902404 modified "2023-09-23" @default.
- W1558902404 title "Barefoot thru' the Valley of Darkness: Preclinical Development of a Human Hookworm Vaccine" @default.
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- W1558902404 doi "https://doi.org/10.1002/9783527652969.ch21" @default.
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