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- W1558904093 abstract "새송이버섯으로부터 활성추적법으로 항암활성이 있는 물질인 에르고스테롤 프록사이드를 분리하였다. 이 스테롤의 구조는 분광법과 NMR법으로 확인하였으며 분자식은 <TEX>$C_{28}H_{44}O_3$</TEX>이었다. 폐암과 난소암에 <TEX>$IC_{50}$</TEX>값은 각각 <TEX>$7{mu}M$</TEX>과 <TEX>$14{mu}M$</TEX>이었다. DNA단편화 실험에서 이 화합물은 암세포의 chromosimal DNA 를 사닥다리모양으로 분해하였고, 세포 분열주기의 억제실험에서 G1단계를 억제함을 관찰하였다. Activity-guided fractionations led to the isolation of antitumor compound, ergosterol peroxide (<TEX>$5{alpha},;8{alpha}-epideoxy-24(R)-methylcholesta-6,;22-dien-3{beta}-ol$</TEX>) from the fruiting body of Pleuratus eryngii that was cultivated artificially. This sterol structure was established by using spectroscopic methods (<TEX>$^1H;and;^{13}C$</TEX> nuclear magnetic resonance and high resolution mass spectra). The purified compound showed a molecular formular of <TEX>$C_{28}H_{44}O_3$</TEX> displaying characteristic features of epidioxy sterols. The 50% inhibitory concentrations (<TEX>$IC_{50}$</TEX>) of ergosterol peroxide against human lung cancer cell line (A549) and human ovarian cell line (SK-OV3) were <TEX>$7{mu}M;and;14{mu}M$</TEX>, respectively. In the DNA fragmentation assay, the compound showed the programmed cell death causing the chromosomal DNA fragmentation. It reveals that ergosterol peroxide arrests G1 phase of the cell division cycle." @default.
- W1558904093 created "2016-06-24" @default.
- W1558904093 date "2006-04-01" @default.
- W1558904093 modified "2023-10-14" @default.
- W1558904093 title "Antitumor Sterol Isolated from the Fruiting Body of Pleurotus eryngii" @default.
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- W1558904093 doi "https://doi.org/10.5352/jls.2006.16.2.282" @default.
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