FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1559096921> ?p ?o ?g. }

• W1559096921 endingPage "434" @default.
• W1559096921 startingPage "429" @default.
• W1559096921 abstract "Summary Objective To investigate whether a polymorphism in the ESR2 gene (rs4986938, previously associated with endometriosis, ovulatory dysfunction and premature onset of coronary heart disease) increases the risk of Graves’ disease (GD). Subjects and design A cohort of 375 GD patients (300 females and 75 males) and 1001 individuals representative of the background population of Poland (502 males and 499 females) were genotyped for rs4986938 using allele‐specific polymerase chain reaction (PCR). Results We found an increased frequency of the ESR2 A allele among the patients vs. controls (38·0% vs. 32·7%, OR = 1·26, P = 0·009) that was caused by a co‐dominant (OR = 1·25, P = 0·01, P for model fit = 0·127) or a recessive (OR = 1·67, P = 0·003, P for model fit = 0·554) effect. The association was found in both sexes (OR = 1·21, P = 0·046 and OR = 1·53, P = 0·029, respectively, for co‐dominant and recessive models in females, and OR = 1·44, P = 0·034 and OR = 2·29, P = 0·01, respectively, for the two models in males) and was more pronounced among the DRB1*03 ‐negative (OR = 1·63, P = 0·0002) than DRB1 * 03 ‐positive patients (OR = 1·04, P = 0·822). No other statistically significant associations between the ESR2 genotype and GD subsets were found (age of onset, smoking, clinically evident ophthalmopathy, family history of GD, and PTPN22 and CTLA4 (CT60) genotypes were analysed). Conclusions In a Polish population the ESR2 A allele is associated with GD with a strength comparable to polymorphisms of PTPN22 and CTLA4 CT60 loci (OR ~ 1·7). The association with ESR2 is found in both sexes and may be particularly strong among the DRB1*03 ‐negative individuals." @default.
• W1559096921 created "2016-06-24" @default.
• W1559096921 creator A5001567130 @default.
• W1559096921 creator A5008470128 @default.
• W1559096921 creator A5034508292 @default.
• W1559096921 creator A5040479770 @default.
• W1559096921 creator A5043172790 @default.
• W1559096921 creator A5046116353 @default.
• W1559096921 creator A5051833516 @default.
• W1559096921 creator A5053210830 @default.
• W1559096921 creator A5073755386 @default.
• W1559096921 creator A5079491798 @default.
• W1559096921 date "2007-09-10" @default.
• W1559096921 modified "2023-10-15" @default.
• W1559096921 title "Polymorphism of the oestrogen receptor beta gene ( <i>ESR2</i> ) is associated with susceptibility to Graves’ disease" @default.
• W1559096921 cites W1550218780 @default.
• W1559096921 cites W1908861496 @default.
• W1559096921 cites W1963960399 @default.
• W1559096921 cites W1966088006 @default.
• W1559096921 cites W1967306941 @default.
• W1559096921 cites W1972970082 @default.
• W1559096921 cites W1977475108 @default.
• W1559096921 cites W1978044136 @default.
• W1559096921 cites W1981854619 @default.
• W1559096921 cites W1999104790 @default.
• W1559096921 cites W2007365962 @default.
• W1559096921 cites W2015418653 @default.
• W1559096921 cites W2033371591 @default.
• W1559096921 cites W2054061067 @default.
• W1559096921 cites W2064063117 @default.
• W1559096921 cites W2074168265 @default.
• W1559096921 cites W2074788705 @default.
• W1559096921 cites W2082273773 @default.
• W1559096921 cites W2089103982 @default.
• W1559096921 cites W2118094114 @default.
• W1559096921 cites W2135167801 @default.
• W1559096921 cites W2142155452 @default.
• W1559096921 cites W2153522663 @default.
• W1559096921 cites W2159089057 @default.
• W1559096921 cites W2161623422 @default.
• W1559096921 cites W2163387976 @default.
• W1559096921 cites W4253899241 @default.
• W1559096921 cites W4256729998 @default.
• W1559096921 doi "https://doi.org/10.1111/j.1365-2265.2007.03060.x" @default.
• W1559096921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17941906" @default.
• W1559096921 hasPublicationYear "2007" @default.
• W1559096921 type Work @default.
• W1559096921 sameAs 1559096921 @default.
• W1559096921 citedByCount "28" @default.
• W1559096921 countsByYear W15590969212012 @default.
• W1559096921 countsByYear W15590969212013 @default.
• W1559096921 countsByYear W15590969212014 @default.
• W1559096921 countsByYear W15590969212015 @default.
• W1559096921 countsByYear W15590969212016 @default.
• W1559096921 countsByYear W15590969212017 @default.
• W1559096921 countsByYear W15590969212018 @default.
• W1559096921 countsByYear W15590969212019 @default.
• W1559096921 countsByYear W15590969212020 @default.
• W1559096921 countsByYear W15590969212021 @default.
• W1559096921 countsByYear W15590969212022 @default.
• W1559096921 crossrefType "journal-article" @default.
• W1559096921 hasAuthorship W1559096921A5001567130 @default.
• W1559096921 hasAuthorship W1559096921A5008470128 @default.
• W1559096921 hasAuthorship W1559096921A5034508292 @default.
• W1559096921 hasAuthorship W1559096921A5040479770 @default.
• W1559096921 hasAuthorship W1559096921A5043172790 @default.
• W1559096921 hasAuthorship W1559096921A5046116353 @default.
• W1559096921 hasAuthorship W1559096921A5051833516 @default.
• W1559096921 hasAuthorship W1559096921A5053210830 @default.
• W1559096921 hasAuthorship W1559096921A5073755386 @default.
• W1559096921 hasAuthorship W1559096921A5079491798 @default.
• W1559096921 hasConcept C104317684 @default.
• W1559096921 hasConcept C126322002 @default.
• W1559096921 hasConcept C134018914 @default.
• W1559096921 hasConcept C135763542 @default.
• W1559096921 hasConcept C149737253 @default.
• W1559096921 hasConcept C180754005 @default.
• W1559096921 hasConcept C2776652619 @default.
• W1559096921 hasConcept C2779134260 @default.
• W1559096921 hasConcept C2908647359 @default.
• W1559096921 hasConcept C37463918 @default.
• W1559096921 hasConcept C54355233 @default.
• W1559096921 hasConcept C71924100 @default.
• W1559096921 hasConcept C86803240 @default.
• W1559096921 hasConcept C99454951 @default.
• W1559096921 hasConceptScore W1559096921C104317684 @default.
• W1559096921 hasConceptScore W1559096921C126322002 @default.
• W1559096921 hasConceptScore W1559096921C134018914 @default.
• W1559096921 hasConceptScore W1559096921C135763542 @default.
• W1559096921 hasConceptScore W1559096921C149737253 @default.
• W1559096921 hasConceptScore W1559096921C180754005 @default.
• W1559096921 hasConceptScore W1559096921C2776652619 @default.
• W1559096921 hasConceptScore W1559096921C2779134260 @default.
• W1559096921 hasConceptScore W1559096921C2908647359 @default.
• W1559096921 hasConceptScore W1559096921C37463918 @default.
• W1559096921 hasConceptScore W1559096921C54355233 @default.
• W1559096921 hasConceptScore W1559096921C71924100 @default.
• W1559096921 hasConceptScore W1559096921C86803240 @default.

• next