FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1559171641> ?p ?o ?g. }

• W1559171641 endingPage "18937" @default.
• W1559171641 startingPage "18929" @default.
• W1559171641 abstract "We have purified putative L-type Ca2+ channels from chick heart by virtue of their associated high affinity receptors for the Ca2+ channel effectors, dihydropyridines (DHPs), and phenylalkylamines (PAAs). A peptide of 185,000-190,000 daltons was found to comigrate with the peak of DHP binding activity during purification through two successive cycles of lectin affinity chromatography and sucrose density gradient centrifugation. A previously described peptide of 140,000 daltons, whose Mr was increased to approximately 180,000 under nonreducing conditions, also copurified with the 185-kDa peptide and dihydropyridine binding activity. When cardiac membranes were photolabeled with either the dihydropyridine [3H]azidopine or the PAA [3H]azidopamil prior to purification, a single, specifically labeled component of 185,000-190,000 daltons was present in the purified fractions. The properties of this 185-kDa cardiac DHP/PAA receptor were compared to the smaller 165-kDa DHP/PAA receptor previously purified from skeletal muscle. Antibodies raised against the 165-kDa skeletal muscle DHP/PAA receptor reacted with both rabbit and chick skeletal muscle receptors, but only poorly recognized, if at all, the cardiac 185-190 kDa component. The 185-kDa peptide present in the purified fractions obtained from cardiac muscle did not undergo substantial phosphorylation by cAMP-dependent protein kinase, while the purified 165-kDa peptide from rabbit and chick skeletal muscle was a good substrate for this kinase. The results show that the DHP and PAA receptors in cardiac muscle are contained in a 185-190-kDa peptide that is significantly larger than, and structurally and immunologically different from, it skeletal muscle counterpart." @default.
• W1559171641 created "2016-06-24" @default.
• W1559171641 creator A5002203462 @default.
• W1559171641 creator A5073386606 @default.
• W1559171641 date "1988-12-01" @default.
• W1559171641 modified "2023-10-05" @default.
• W1559171641 title "Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different." @default.
• W1559171641 cites W1487828245 @default.
• W1559171641 cites W1506008139 @default.
• W1559171641 cites W1514747567 @default.
• W1559171641 cites W1538727673 @default.
• W1559171641 cites W1563654697 @default.
• W1559171641 cites W1566114810 @default.
• W1559171641 cites W1567869946 @default.
• W1559171641 cites W1570544530 @default.
• W1559171641 cites W1605993021 @default.
• W1559171641 cites W1740533879 @default.
• W1559171641 cites W1888388363 @default.
• W1559171641 cites W1954353020 @default.
• W1559171641 cites W1966353533 @default.
• W1559171641 cites W1971423696 @default.
• W1559171641 cites W1974164985 @default.
• W1559171641 cites W1975330371 @default.
• W1559171641 cites W1980444911 @default.
• W1559171641 cites W1985715879 @default.
• W1559171641 cites W1991846269 @default.
• W1559171641 cites W1993287181 @default.
• W1559171641 cites W1997868744 @default.
• W1559171641 cites W2009292667 @default.
• W1559171641 cites W2010946083 @default.
• W1559171641 cites W2016574532 @default.
• W1559171641 cites W2018931883 @default.
• W1559171641 cites W2019813089 @default.
• W1559171641 cites W2024929666 @default.
• W1559171641 cites W2031087233 @default.
• W1559171641 cites W2037048489 @default.
• W1559171641 cites W2038659436 @default.
• W1559171641 cites W2040001266 @default.
• W1559171641 cites W2042148321 @default.
• W1559171641 cites W2042217106 @default.
• W1559171641 cites W2044555557 @default.
• W1559171641 cites W2047896617 @default.
• W1559171641 cites W2049768827 @default.
• W1559171641 cites W2054885505 @default.
• W1559171641 cites W2060533392 @default.
• W1559171641 cites W2064123037 @default.
• W1559171641 cites W2076378327 @default.
• W1559171641 cites W2078539274 @default.
• W1559171641 cites W2085550628 @default.
• W1559171641 cites W2094362927 @default.
• W1559171641 cites W2100837269 @default.
• W1559171641 cites W2114276844 @default.
• W1559171641 cites W2128749127 @default.
• W1559171641 cites W2131649189 @default.
• W1559171641 cites W2136467501 @default.
• W1559171641 cites W2141226958 @default.
• W1559171641 doi "https://doi.org/10.1016/s0021-9258(18)37371-x" @default.
• W1559171641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2848812" @default.
• W1559171641 hasPublicationYear "1988" @default.
• W1559171641 type Work @default.
• W1559171641 sameAs 1559171641 @default.
• W1559171641 citedByCount "93" @default.
• W1559171641 countsByYear W15591716412012 @default.
• W1559171641 countsByYear W15591716412013 @default.
• W1559171641 countsByYear W15591716412014 @default.
• W1559171641 countsByYear W15591716412016 @default.
• W1559171641 countsByYear W15591716412017 @default.
• W1559171641 countsByYear W15591716412018 @default.
• W1559171641 countsByYear W15591716412022 @default.
• W1559171641 crossrefType "journal-article" @default.
• W1559171641 hasAuthorship W1559171641A5002203462 @default.
• W1559171641 hasAuthorship W1559171641A5073386606 @default.
• W1559171641 hasBestOaLocation W15591716411 @default.
• W1559171641 hasConcept C113217602 @default.
• W1559171641 hasConcept C12554922 @default.
• W1559171641 hasConcept C126322002 @default.
• W1559171641 hasConcept C134018914 @default.
• W1559171641 hasConcept C170493617 @default.
• W1559171641 hasConcept C178790620 @default.
• W1559171641 hasConcept C185592680 @default.
• W1559171641 hasConcept C2778996579 @default.
• W1559171641 hasConcept C2779959927 @default.
• W1559171641 hasConcept C2781212610 @default.
• W1559171641 hasConcept C519063684 @default.
• W1559171641 hasConcept C55493867 @default.
• W1559171641 hasConcept C71924100 @default.
• W1559171641 hasConcept C86803240 @default.
• W1559171641 hasConceptScore W1559171641C113217602 @default.
• W1559171641 hasConceptScore W1559171641C12554922 @default.
• W1559171641 hasConceptScore W1559171641C126322002 @default.
• W1559171641 hasConceptScore W1559171641C134018914 @default.
• W1559171641 hasConceptScore W1559171641C170493617 @default.
• W1559171641 hasConceptScore W1559171641C178790620 @default.
• W1559171641 hasConceptScore W1559171641C185592680 @default.
• W1559171641 hasConceptScore W1559171641C2778996579 @default.
• W1559171641 hasConceptScore W1559171641C2779959927 @default.
• W1559171641 hasConceptScore W1559171641C2781212610 @default.
• W1559171641 hasConceptScore W1559171641C519063684 @default.

• next