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- W1559172020 abstract "To mimic cerebral ischemia leading to stroke in man, many animal models have been made which occlude brain arteries, transiently or permanently. These models are aimed at studying the morphological changes and the pathophysiology of stroke, and at screening and testing new neuroprotective or thrombolytic drugs. When compared with the model making use of a craniotomy to permanently occlude the cerebral arteries, the model of the middle cerebral artery occlusion using the intraluminal filament in rats considerably decreased the additional surgical trauma due to the experimental procedure. Despite the advantages of this widespread method, a refinement of the model was needed to reduce the mortality rate, ameliorate the reproducibility of the ischemic lesion and to better imitate the pathophysiological situation of stroke in man. We report here the refinement of the permanent cerebral ischemia models in rats leading to an exclusive and selective occlusion of the middle cerebral artery, a full restoration of the blood flow in the ipsilateral common carotid artery and a less severe and invasive surgical intervention. Moreover, some of these improvements may also be used to improve the transient cerebral ischemia model." @default.
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- W1559172020 date "2008-01-01" @default.
- W1559172020 modified "2023-09-26" @default.
- W1559172020 title "Occlusion of the Middle Cerebral Artery in Rats" @default.
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- W1559172020 doi "https://doi.org/10.1159/000117723" @default.
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