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- W1559457613 abstract "The hypothalamic component of HPA–axis CRH is also produced by the placenta and ithas been postulated to control a “placental clock” during pregnancy which determinesthe onset of parturition. However, the role of CRH in early trophoblast biology iscurrently unknown. In this thesis we investigated the role of CRH/CRH receptor in earlyplacentation using the fusigenic choriocarcinoma cell line BeWo.These cells expressed functional CRH-R coupled to MAPK signalling cascades. In thiscellular model, CRH was shown to promote survival and to induce cell proliferation,however in the presence of differentiation-inducing signals (such as forskolin) CRHfurther augmented up-regulation of fusogenic gene expression and hCG secretioninduced by forskolin. Therefore, placental CRH appears to influence placenta biology.Finally, it was shown for the first time that CRH actions were sensitive to TLR4activation raising the possibility that the innate immune system is an important regulatorof placental CRH biological actions." @default.
- W1559457613 created "2016-06-24" @default.
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- W1559457613 date "2011-01-01" @default.
- W1559457613 modified "2023-09-23" @default.
- W1559457613 title "The role of CRH in placental biology : studies employing a choriocarcinoma cell line" @default.
- W1559457613 hasPublicationYear "2011" @default.
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