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• W1559492060 abstract "The discovery of leptin, this hormone originating from adipocytes, has generated an extraordinary interest in the understanding of the relationship between metabolic status and the neuroendocrine system, in particular, the neuroendocrine regulation of reproduction. Following the initial demonstration that leptin administration to leptin-deficient, sterile ob/ob mice could activate their reproductive axis, and also that treatment of fasting, normal mice with leptin could protect neuroendocrine secretions and prevent the changes that are associated with fasting, the concept has emerged that a normal leptin secretion is a prerequisite for normal reproductive function, leptin acting as a permissive factor. Initiation and maintenance of normal reproductive capacity necessitate adequate metabolic conditions. The time for initiation of puberty has been associated with proper advance in acquisition in body weight or body fat and/or harmonious eating habits. Malnutrition, either inadequate caloric or protein intake, has been associated with delay in puberty or inactivation of the hypothalamo-pituitary gonadal axis. Eating disorders are known to affect gonadal function such as the typical situation of anorexia nervosa, or self-inflicted food restriction, that rapidly results in hypogonadism. Internal cues related to metabolism or nutrition, among them, leptin plasma level, could not only affect the hypothalamic stimulation of the gonadotropic axis, but also modify sexual behavior. Several unfavorable metabolic situations, as they can be studied in animal models, are associated with low plasma leptin, increased secretion of hypothalamic Neuropeptide Y (NPY), and" @default.
• W1559492060 created "2016-06-24" @default.
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• W1559492060 date "2000-01-01" @default.
• W1559492060 modified "2023-09-22" @default.
• W1559492060 title "Leptin and human reproduction" @default.
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