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• W1559496412 startingPage "704" @default.
• W1559496412 abstract "ABSTRACT: Recently, we reported that male accessory sex gland (ASG) secretions protect sperm genomic integrity by demonstrating that DNA damage was more extensive in sperm not exposed to the secretions. The present study was conducted to find out if ASGs secrete the main antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx or GSH-Px), and catalase (CAT) and if the most abundant one, SOD, can protect those sperm that were not exposed to ASG secretions against NADPH-induced oxidative stress. Four experimental groups of male golden hamsters were used: intact animals with proven fertility, animals with all major ASGs removed (TX), animals that were bilaterally vasectomized, and sham-operated controls. SOD, CAT, and GPx activities were measured in secretions from all 5 ASGs and sperm-free uterine flushing from virgin females and those mated with the experimental males. The alkaline comet assay was used to analyze DNA integrity of the TX group sperm after incubation in a medium containing 50 U/mL of SOD along with 0 to 20 mmol/L NADPH. The main antioxidant enzyme in ASGs was SOD from coagulating glands (P < .05) and GPx together with CAT from ampullary glands (P < .05). Uterine flushing of ejaculates that contained ASG secretions had more SOD and CAT activities than those with epididymal secretions alone (P < .05 and P < .001, respectively), whereas activity of GPx was the same (P > .05). Addition of SOD in vitro dose dependently decreased the incidence of single-strand DNA damage in sperm not exposed to ASG secretions incubated in the presence of 0 to 20 mmol/L NADPH (P < .001). These results indicated that, in terms of abundance, SOD was the main antioxidant enzyme secreted by male ASGs, whereas CAT was the second one. The GPx activity came from both epididymis and ASGs. We conclude that ASG secretions play a significant role in protecting sperm against oxidative stress." @default.
• W1559496412 created "2016-06-24" @default.
• W1559496412 creator A5009527352 @default.
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• W1559496412 creator A5054032752 @default.
• W1559496412 creator A5064530138 @default.
• W1559496412 date "2003-09-10" @default.
• W1559496412 modified "2023-10-05" @default.
• W1559496412 title "Male Genital Tract Antioxidant Enzymes: Their Source, Function in the Female, and Ability to Preserve Sperm DNA Integrity in the Golden Hamster" @default.
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• W1559496412 cites W1684021943 @default.
• W1559496412 cites W1932977957 @default.
• W1559496412 cites W1946127076 @default.
• W1559496412 cites W1975223491 @default.
• W1559496412 cites W1975350721 @default.
• W1559496412 cites W1978592015 @default.
• W1559496412 cites W1983862828 @default.
• W1559496412 cites W1984050801 @default.
• W1559496412 cites W1985653501 @default.
• W1559496412 cites W1989564054 @default.
• W1559496412 cites W1991814119 @default.
• W1559496412 cites W1992313587 @default.
• W1559496412 cites W1992424979 @default.
• W1559496412 cites W1994157894 @default.
• W1559496412 cites W1996272845 @default.
• W1559496412 cites W1996944297 @default.
• W1559496412 cites W2001507834 @default.
• W1559496412 cites W2002295776 @default.
• W1559496412 cites W2007400083 @default.
• W1559496412 cites W2011010922 @default.
• W1559496412 cites W2012326018 @default.
• W1559496412 cites W2012787537 @default.
• W1559496412 cites W2021146142 @default.
• W1559496412 cites W2023362705 @default.
• W1559496412 cites W2029053945 @default.
• W1559496412 cites W2032935454 @default.
• W1559496412 cites W2035943099 @default.
• W1559496412 cites W2040316987 @default.
• W1559496412 cites W2046093069 @default.
• W1559496412 cites W2046459616 @default.
• W1559496412 cites W2049571107 @default.
• W1559496412 cites W2052178794 @default.
• W1559496412 cites W2062244473 @default.
• W1559496412 cites W2063129023 @default.
• W1559496412 cites W2065442940 @default.
• W1559496412 cites W2079436545 @default.
• W1559496412 cites W2082624234 @default.
• W1559496412 cites W2087491434 @default.
• W1559496412 cites W2089285434 @default.
• W1559496412 cites W2092206306 @default.
• W1559496412 cites W2092629964 @default.
• W1559496412 cites W2096206245 @default.
• W1559496412 cites W2102235874 @default.
• W1559496412 cites W2108016209 @default.
• W1559496412 cites W2112592664 @default.
• W1559496412 cites W2115794619 @default.
• W1559496412 cites W2116932540 @default.
• W1559496412 cites W2117322076 @default.
• W1559496412 cites W2119408897 @default.
• W1559496412 cites W2120433044 @default.
• W1559496412 cites W2121032997 @default.
• W1559496412 cites W2127048961 @default.
• W1559496412 cites W2130516623 @default.
• W1559496412 cites W2132774278 @default.
• W1559496412 cites W2134048627 @default.
• W1559496412 cites W2135982134 @default.
• W1559496412 cites W2140816346 @default.
• W1559496412 cites W2143468659 @default.
• W1559496412 cites W2148078757 @default.
• W1559496412 cites W2149819908 @default.
• W1559496412 cites W2154344325 @default.
• W1559496412 cites W2156541092 @default.
• W1559496412 cites W2165463199 @default.
• W1559496412 cites W2166534802 @default.
• W1559496412 cites W2170794875 @default.
• W1559496412 cites W2272838734 @default.
• W1559496412 cites W2313370013 @default.
• W1559496412 cites W2316993960 @default.
• W1559496412 cites W4243574300 @default.
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• W1559496412 doi "https://doi.org/10.1002/j.1939-4640.2003.tb02730.x" @default.
• W1559496412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12954661" @default.
• W1559496412 hasPublicationYear "2003" @default.
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