Matches in SemOpenAlex for { <https://semopenalex.org/work/W1559528094> ?p ?o ?g. }
- W1559528094 endingPage "890" @default.
- W1559528094 startingPage "881" @default.
- W1559528094 abstract "Type I interferons (IFNs) are secreted cytokines that orchestrate diverse immune responses to infection. Although typically considered to be most important in the response to viruses, type I IFNs are also induced by most, if not all, bacterial pathogens. Although diverse mechanisms have been described, bacterial induction of type I IFNs occurs upon stimulation of two main pathways: (i) Toll-like receptor (TLR) recognition of bacterial molecules such as lipopolysaccharide (LPS); (ii) TLR-independent recognition of molecules delivered to the host cell cytosol. Cytosolic responses can be activated by two general mechanisms. First, viable bacteria can secrete stimulatory ligands into the cytosol via specialized bacterial secretion systems. Second, ligands can be released from bacteria that lyse or are degraded. The bacterial ligands that induce the cytosolic pathways remain uncertain in many cases, but appear to include various nucleic acids. In this review, we discuss recent advances in our understanding of how bacteria induce type I interferons and the roles type I IFNs play in host immunity." @default.
- W1559528094 created "2016-06-24" @default.
- W1559528094 creator A5005881707 @default.
- W1559528094 creator A5023018609 @default.
- W1559528094 creator A5061473047 @default.
- W1559528094 date "2010-05-06" @default.
- W1559528094 modified "2023-10-16" @default.
- W1559528094 title "Induction of type I interferons by bacteria" @default.
- W1559528094 cites W1575269241 @default.
- W1559528094 cites W1593235986 @default.
- W1559528094 cites W1599168371 @default.
- W1559528094 cites W1614324271 @default.
- W1559528094 cites W1677669763 @default.
- W1559528094 cites W1804116733 @default.
- W1559528094 cites W1899835135 @default.
- W1559528094 cites W1940294549 @default.
- W1559528094 cites W1957173764 @default.
- W1559528094 cites W1964141567 @default.
- W1559528094 cites W1969601023 @default.
- W1559528094 cites W1980223460 @default.
- W1559528094 cites W1980376664 @default.
- W1559528094 cites W1982667029 @default.
- W1559528094 cites W1991185062 @default.
- W1559528094 cites W1991858276 @default.
- W1559528094 cites W1993832002 @default.
- W1559528094 cites W2009101093 @default.
- W1559528094 cites W2009127910 @default.
- W1559528094 cites W2014960200 @default.
- W1559528094 cites W2017515700 @default.
- W1559528094 cites W2024296071 @default.
- W1559528094 cites W2028792773 @default.
- W1559528094 cites W2031182394 @default.
- W1559528094 cites W2031269216 @default.
- W1559528094 cites W2032948492 @default.
- W1559528094 cites W2038121714 @default.
- W1559528094 cites W2040665228 @default.
- W1559528094 cites W2052566477 @default.
- W1559528094 cites W2053429123 @default.
- W1559528094 cites W2060004514 @default.
- W1559528094 cites W2062436911 @default.
- W1559528094 cites W2062490839 @default.
- W1559528094 cites W2066974855 @default.
- W1559528094 cites W2077648685 @default.
- W1559528094 cites W2078342014 @default.
- W1559528094 cites W2081535038 @default.
- W1559528094 cites W2082889122 @default.
- W1559528094 cites W2083813609 @default.
- W1559528094 cites W2089712328 @default.
- W1559528094 cites W2093012198 @default.
- W1559528094 cites W2095401221 @default.
- W1559528094 cites W2095495335 @default.
- W1559528094 cites W2098188064 @default.
- W1559528094 cites W2101141686 @default.
- W1559528094 cites W2104195963 @default.
- W1559528094 cites W2110456507 @default.
- W1559528094 cites W2110864354 @default.
- W1559528094 cites W2111428445 @default.
- W1559528094 cites W2113295282 @default.
- W1559528094 cites W2113757071 @default.
- W1559528094 cites W2116803339 @default.
- W1559528094 cites W2119242392 @default.
- W1559528094 cites W2122822209 @default.
- W1559528094 cites W2123440892 @default.
- W1559528094 cites W2123697121 @default.
- W1559528094 cites W2125566625 @default.
- W1559528094 cites W2127684626 @default.
- W1559528094 cites W2127728157 @default.
- W1559528094 cites W2133006561 @default.
- W1559528094 cites W2136327827 @default.
- W1559528094 cites W2136736147 @default.
- W1559528094 cites W2138660148 @default.
- W1559528094 cites W2144014651 @default.
- W1559528094 cites W2145638464 @default.
- W1559528094 cites W2145990658 @default.
- W1559528094 cites W2149014007 @default.
- W1559528094 cites W2150058561 @default.
- W1559528094 cites W2151109138 @default.
- W1559528094 cites W2151684454 @default.
- W1559528094 cites W2157117327 @default.
- W1559528094 cites W2157305255 @default.
- W1559528094 cites W2158342892 @default.
- W1559528094 cites W2165748936 @default.
- W1559528094 cites W2167121345 @default.
- W1559528094 doi "https://doi.org/10.1111/j.1462-5822.2010.01478.x" @default.
- W1559528094 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2897911" @default.
- W1559528094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20482555" @default.
- W1559528094 hasPublicationYear "2010" @default.
- W1559528094 type Work @default.
- W1559528094 sameAs 1559528094 @default.
- W1559528094 citedByCount "130" @default.
- W1559528094 countsByYear W15595280942012 @default.
- W1559528094 countsByYear W15595280942013 @default.
- W1559528094 countsByYear W15595280942014 @default.
- W1559528094 countsByYear W15595280942015 @default.
- W1559528094 countsByYear W15595280942016 @default.
- W1559528094 countsByYear W15595280942017 @default.
- W1559528094 countsByYear W15595280942018 @default.
- W1559528094 countsByYear W15595280942019 @default.