Matches in SemOpenAlex for { <https://semopenalex.org/work/W1559532885> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W1559532885 abstract "Abstract A formal total synthesis of perhydrohistrionicotoxin (H 12 -HTX) is described based on a stereocontrolled α-acyliminium ion-olefin cyclisation. In the key step of the synthesis three asymmetric C atoms (C 6 C 7 and C 8 ) are introduced in a single operation leading to the formation of the spiro formate ester 15 . Compound 15 is converted to the spirothiolactam alcohol 17 , a known precursor of H 12 -HTX. The versatility of the synthetic approach is further demonstrated by the stereocontrolled syntheses of other functionalized 1-azaspirans, viz the 6- Endo -Trig products 20 and 24 and the 5- Exo -Trig products 26 and 28 . The formation of the latter two compounds is remarkable with respect to the mechanism. 13 C NMR data of a series of 1-azaspirans are provided, which inter alia show the existence of a conformational equilibrium in 1-azaspiro alcohol 16 ,Mass spectral criteria are used for assignment 5- Exo -or 6- Endo -cyclisation products." @default.
- W1559532885 created "2016-06-24" @default.
- W1559532885 creator A5070275733 @default.
- W1559532885 creator A5070447302 @default.
- W1559532885 date "1980-07-22" @default.
- W1559532885 modified "2023-09-24" @default.
- W1559532885 title "ChemInform Abstract: STEREOCONTROLLED SYNTHESIS OF FUNCTIONALIZED 1-AZASPIRANS. EFFICIENT SYNTHESIS OF PERHYDROHISTRIONICOTOXIN" @default.
- W1559532885 cites W2955726386 @default.
- W1559532885 doi "https://doi.org/10.1002/chin.198029339" @default.
- W1559532885 hasPublicationYear "1980" @default.
- W1559532885 type Work @default.
- W1559532885 sameAs 1559532885 @default.
- W1559532885 citedByCount "2" @default.
- W1559532885 crossrefType "journal-article" @default.
- W1559532885 hasAuthorship W1559532885A5070275733 @default.
- W1559532885 hasAuthorship W1559532885A5070447302 @default.
- W1559532885 hasConcept C161790260 @default.
- W1559532885 hasConcept C178790620 @default.
- W1559532885 hasConcept C185592680 @default.
- W1559532885 hasConcept C21951064 @default.
- W1559532885 hasConcept C2780178953 @default.
- W1559532885 hasConcept C2781066024 @default.
- W1559532885 hasConcept C2985598853 @default.
- W1559532885 hasConcept C51886252 @default.
- W1559532885 hasConcept C71240020 @default.
- W1559532885 hasConceptScore W1559532885C161790260 @default.
- W1559532885 hasConceptScore W1559532885C178790620 @default.
- W1559532885 hasConceptScore W1559532885C185592680 @default.
- W1559532885 hasConceptScore W1559532885C21951064 @default.
- W1559532885 hasConceptScore W1559532885C2780178953 @default.
- W1559532885 hasConceptScore W1559532885C2781066024 @default.
- W1559532885 hasConceptScore W1559532885C2985598853 @default.
- W1559532885 hasConceptScore W1559532885C51886252 @default.
- W1559532885 hasConceptScore W1559532885C71240020 @default.
- W1559532885 hasLocation W15595328851 @default.
- W1559532885 hasOpenAccess W1559532885 @default.
- W1559532885 hasPrimaryLocation W15595328851 @default.
- W1559532885 hasRelatedWork W1600860244 @default.
- W1559532885 hasRelatedWork W1622045162 @default.
- W1559532885 hasRelatedWork W2017294218 @default.
- W1559532885 hasRelatedWork W203907913 @default.
- W1559532885 hasRelatedWork W2058268772 @default.
- W1559532885 hasRelatedWork W2066171914 @default.
- W1559532885 hasRelatedWork W2067232715 @default.
- W1559532885 hasRelatedWork W2087811727 @default.
- W1559532885 hasRelatedWork W2090038338 @default.
- W1559532885 hasRelatedWork W2136438089 @default.
- W1559532885 hasRelatedWork W2174317427 @default.
- W1559532885 hasRelatedWork W2528808355 @default.
- W1559532885 hasRelatedWork W2919069992 @default.
- W1559532885 hasRelatedWork W2949578786 @default.
- W1559532885 hasRelatedWork W2949788301 @default.
- W1559532885 hasRelatedWork W2951324802 @default.
- W1559532885 hasRelatedWork W2952181007 @default.
- W1559532885 hasRelatedWork W2955726386 @default.
- W1559532885 hasRelatedWork W764471231 @default.
- W1559532885 hasRelatedWork W798263672 @default.
- W1559532885 isParatext "false" @default.
- W1559532885 isRetracted "false" @default.
- W1559532885 magId "1559532885" @default.
- W1559532885 workType "article" @default.