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- W1559664403 abstract "A positive family history of hypertension (+FH) is a risk factor for the future development of hypertension. Reductions in cardiovagal baroreflex sensitivity (BRS) are also associated with hypertension and cardiovascular disease. Therefore, we hypothesized that young women with +FH (n=13, 22±1 yrs, 21±1 kg/m2, 84±2 mmHg resting mean blood pressure (BP)) would have lower BRS compared to young women without a family history of hypertension (-FH; n=11, 21±1 yrs, 22±1 kg/m2, 81±3 mmHg resting mean BP, all P>0.05 between groups). We examined BRS as the relationship between systolic BP and R-R intervals during phases II and IV of the Valsalva maneuver. The slope of the relationship between systolic BP and R-R interval was determined using linear regression, and used as an index of cardiovagal BRS. We accepted linear regressions with an r > 0.70 for analysis. Cardiovagal BRS was similar during phase II of the Valsalva maneuver (Mean slope: +FH 6.1±0.8 vs. -FH 6.4±1.6, P=0.87). However, cardiovagal BRS during phase IV of the Valsalva maneuver tended to be lower in the +FH group (+FH n=10, -FH n=8, mean slope: +FH 9.3±2.2 vs. -FH 15.3±2.2, P=0.07). Mean BP (+FH 80±1 mmHg, -FH 78±2 mmHg) and resting heart rate (+FH 63±3 bpm, -FH 66±2 bpm) during the experimental visit were similar between groups. These preliminary data suggest that women with a positive family history of hypertension may have reduced cardiovagal BRS. This may be one mechanism contributing to the development of future hypertension in those with a family history. This work was supported in part by NIH Grant U54-GM104941 (PI: Binder-Macleod)." @default.
- W1559664403 created "2016-06-24" @default.
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- W1559664403 date "2015-04-01" @default.
- W1559664403 modified "2023-09-23" @default.
- W1559664403 title "Baroreflex Function in Young Women with a Family History of Hypertension" @default.
- W1559664403 doi "https://doi.org/10.1096/fasebj.29.1_supplement.648.1" @default.
- W1559664403 hasPublicationYear "2015" @default.
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