Matches in SemOpenAlex for { <https://semopenalex.org/work/W1559842180> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1559842180 endingPage "3134" @default.
- W1559842180 startingPage "3126" @default.
- W1559842180 abstract "Abstract The biosynthesis, processing, and assembly of the TCR alpha- and beta-chains with each other and with the CD3 complex were investigated on both cell surface positive (TCR+CD3-) and negative (TCR-CD3-) cell lines. The results indicate that 1) in cell surface TCR-CD3- cell lines (MOLT 3, CCRF-CEM), TCR-beta, but not alpha-chains are present intracellularly. TCR-beta-CD3 complexes are readily found in these cell lines, but no evidence for final processing or cell surface expression of such incomplete TCR-CD3 complexes is observed. 2) In the cell surface TCR+CD3+ cell line HPB-ALL, both alpha- and beta-chains are present intracellularly. Whereas non-glycosylated forms of TCR-beta chain can be detected, only more mature forms of TCR alpha-chains are detected indicating that the alpha-chains are more rapidly glycosylated than the beta-chains. 3) The large majority of the intracellular alpha- and beta-chains is not disulfide linked and a small fraction of these is associated with CD3. 4) Only small amounts of the total intracellular TCR chains are found as CD3-associated disulfide-linked alpha beta-heterodimers. 5) Final processing of TCR chains for cell surface expression takes place after formation of these TCR-alpha beta-CD3 complexes. Thus, both the TCR alpha- and beta-chains are over-produced and only relatively small amounts of these chains form CD3-associated heterodimers that are processed for cell surface expression. Analogous results were obtained with a non-leukemic CTL clone. Based on these observations, a model for the biosynthesis and assembly of the TCR-CD3 complex is presented." @default.
- W1559842180 created "2016-06-24" @default.
- W1559842180 creator A5017849951 @default.
- W1559842180 creator A5032914350 @default.
- W1559842180 creator A5057573005 @default.
- W1559842180 creator A5064835819 @default.
- W1559842180 creator A5091133708 @default.
- W1559842180 date "1988-05-01" @default.
- W1559842180 modified "2023-10-10" @default.
- W1559842180 title "The biosynthesis and assembly of T cell receptor alpha- and beta-chains with the CD3 complex." @default.
- W1559842180 doi "https://doi.org/10.4049/jimmunol.140.9.3126" @default.
- W1559842180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2966207" @default.
- W1559842180 hasPublicationYear "1988" @default.
- W1559842180 type Work @default.
- W1559842180 sameAs 1559842180 @default.
- W1559842180 citedByCount "24" @default.
- W1559842180 countsByYear W15598421802012 @default.
- W1559842180 countsByYear W15598421802013 @default.
- W1559842180 countsByYear W15598421802021 @default.
- W1559842180 crossrefType "journal-article" @default.
- W1559842180 hasAuthorship W1559842180A5017849951 @default.
- W1559842180 hasAuthorship W1559842180A5032914350 @default.
- W1559842180 hasAuthorship W1559842180A5057573005 @default.
- W1559842180 hasAuthorship W1559842180A5064835819 @default.
- W1559842180 hasAuthorship W1559842180A5091133708 @default.
- W1559842180 hasBestOaLocation W15598421801 @default.
- W1559842180 hasConcept C104317684 @default.
- W1559842180 hasConcept C114684123 @default.
- W1559842180 hasConcept C147483822 @default.
- W1559842180 hasConcept C152204938 @default.
- W1559842180 hasConcept C153911025 @default.
- W1559842180 hasConcept C167672396 @default.
- W1559842180 hasConcept C170493617 @default.
- W1559842180 hasConcept C185592680 @default.
- W1559842180 hasConcept C19317047 @default.
- W1559842180 hasConcept C199360897 @default.
- W1559842180 hasConcept C2776090121 @default.
- W1559842180 hasConcept C2776174256 @default.
- W1559842180 hasConcept C41008148 @default.
- W1559842180 hasConcept C54355233 @default.
- W1559842180 hasConcept C55493867 @default.
- W1559842180 hasConcept C79879829 @default.
- W1559842180 hasConcept C81089528 @default.
- W1559842180 hasConcept C81885089 @default.
- W1559842180 hasConcept C86803240 @default.
- W1559842180 hasConcept C8891405 @default.
- W1559842180 hasConcept C95444343 @default.
- W1559842180 hasConceptScore W1559842180C104317684 @default.
- W1559842180 hasConceptScore W1559842180C114684123 @default.
- W1559842180 hasConceptScore W1559842180C147483822 @default.
- W1559842180 hasConceptScore W1559842180C152204938 @default.
- W1559842180 hasConceptScore W1559842180C153911025 @default.
- W1559842180 hasConceptScore W1559842180C167672396 @default.
- W1559842180 hasConceptScore W1559842180C170493617 @default.
- W1559842180 hasConceptScore W1559842180C185592680 @default.
- W1559842180 hasConceptScore W1559842180C19317047 @default.
- W1559842180 hasConceptScore W1559842180C199360897 @default.
- W1559842180 hasConceptScore W1559842180C2776090121 @default.
- W1559842180 hasConceptScore W1559842180C2776174256 @default.
- W1559842180 hasConceptScore W1559842180C41008148 @default.
- W1559842180 hasConceptScore W1559842180C54355233 @default.
- W1559842180 hasConceptScore W1559842180C55493867 @default.
- W1559842180 hasConceptScore W1559842180C79879829 @default.
- W1559842180 hasConceptScore W1559842180C81089528 @default.
- W1559842180 hasConceptScore W1559842180C81885089 @default.
- W1559842180 hasConceptScore W1559842180C86803240 @default.
- W1559842180 hasConceptScore W1559842180C8891405 @default.
- W1559842180 hasConceptScore W1559842180C95444343 @default.
- W1559842180 hasIssue "9" @default.
- W1559842180 hasLocation W15598421801 @default.
- W1559842180 hasLocation W15598421802 @default.
- W1559842180 hasOpenAccess W1559842180 @default.
- W1559842180 hasPrimaryLocation W15598421801 @default.
- W1559842180 hasRelatedWork W1808357240 @default.
- W1559842180 hasRelatedWork W1969516523 @default.
- W1559842180 hasRelatedWork W2003301929 @default.
- W1559842180 hasRelatedWork W2016026615 @default.
- W1559842180 hasRelatedWork W2023675030 @default.
- W1559842180 hasRelatedWork W2069971243 @default.
- W1559842180 hasRelatedWork W2110363972 @default.
- W1559842180 hasRelatedWork W2168412386 @default.
- W1559842180 hasRelatedWork W2232425076 @default.
- W1559842180 hasRelatedWork W2949451120 @default.
- W1559842180 hasVolume "140" @default.
- W1559842180 isParatext "false" @default.
- W1559842180 isRetracted "false" @default.
- W1559842180 magId "1559842180" @default.
- W1559842180 workType "article" @default.