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- W1559917811 abstract "textabstractHematopoiesis or blood cell formation is a strictly regulated process that, inadult individuals, takes place mainly in the bone marrow. All blood cells are derivedfrom a small population of pluripotent stem cells that are capable of self-renewal anddifferentiation towards distinct lineage-committed progenitor cells. These committedprogenitor cells can undergo proliferation followed by terminal differentiation intomature blood cells that include granulocytes, monocytes/macrophages, lymphocytes,erythrocytes, and platelets. Most mature blood cells have a limited life span and needto be replenished constantly. This continuous production is tightly balanced and isregulated essentially by two mechanisms. Stromal cells in the bone marrow affecthematopoiesis by direct cell-to-cell contact and provide a suitable microenvironmentrequired for hematopoietic cell development. In addition, a network of cytokines andhematopoietic growth factors (HGF) specifically control the proliferation,differentiation, survival, and function of different hematopoietic cells. This network isparticularly important under stress conditions, such as infection or bleeding, when arapid rise in specific blood cell types is needed." @default.
- W1559917811 created "2016-06-24" @default.
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- W1559917811 date "1999-03-10" @default.
- W1559917811 modified "2023-09-23" @default.
- W1559917811 title "The role of granulocyte colony-stimulating factor receptor signaling in neutrophil development" @default.
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