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- W1559919026 abstract "Distinct transcriptional regulatory sequences located within the upstream sequences required for p40x trans-activation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) were chemically synthesized and cloned upstream of the basal HTLV-I LTR promoter. Plasmids containing a single 21-base-pair (bp) repeat were weakly inducible by p40x. The level of trans-activation by p40x was increased when two (30-fold) or three (40-fold) 21-bp repeats were present in the upstream control region. In the mutant containing two 21-bp repeats, the upstream 21-bp repeat could be positioned in either the sense (30-fold) or the antisense (16-fold) orientation. Plasmids containing a 51-bp repeat element, which included a single 21-bp repeat, were induced to levels similar to that obtained with the 21-bp repeat sequence alone. Template DNAs containing a single copy of the HTLV-I sequences between -117 and -160 were stimulated approximately 10-fold by p40x when one copy of the 21-bp element was located downstream." @default.
- W1559919026 created "2016-06-24" @default.
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- W1559919026 date "1987-07-01" @default.
- W1559919026 modified "2023-09-23" @default.
- W1559919026 title "Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat" @default.
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- W1559919026 doi "https://doi.org/10.1128/jvi.61.7.2175-2181.1987" @default.
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