Matches in SemOpenAlex for { <https://semopenalex.org/work/W1559940471> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1559940471 endingPage "65.10" @default.
- W1559940471 startingPage "65.10" @default.
- W1559940471 abstract "Abstract Successful aging has been defined as functional resilience in late life despite history of chronic disease and/or concurrent medical conditions. Old age therefore may not be synonymous with ill health. We reported that octo-/nonagenarians who are survivors of a long-term cohort of aging have a distinct T cell repertoire expressing diverse NK-related receptors (NKR). Frequency of these unusual T cells is correlated with unimpaired physical/cognitive function. To determine whether broader repertoire remodeling relates to general well being, we recruited a new cohort of community dwelling elders aged >65 years. Results showed physical/cognitive ability is unrelated with systemic cytokines, but with high levels of NKR on both T and NK cells, and brain-derived neurotrophic factor (BDNF) in plasma. Bioassays showed NKR ligation is sufficient to induce T/NK cell activation, and an unexpected production of BDNF. BDNF in culture supernatants and plasma was biologically active as determined by measurable impact on autocrine T/NK cell activation, and on paracrine neurite sprouting and myotube function. Clearly, physical/cognitive resilience is linked to remodeling of the immune cell repertoire. T/NK-derived BDNF indicate unique communication circuit(s) of immune, physical, and cognitive function domains. Unraveling NKR-driven non-TCR centric immunopathway(s) will be key to the development of age-appropriate, group-targeted strategies to promote healthy longevity." @default.
- W1559940471 created "2016-06-24" @default.
- W1559940471 creator A5000503897 @default.
- W1559940471 creator A5005652638 @default.
- W1559940471 creator A5006850098 @default.
- W1559940471 creator A5032846886 @default.
- W1559940471 creator A5055648700 @default.
- W1559940471 creator A5057234091 @default.
- W1559940471 creator A5078687726 @default.
- W1559940471 date "2014-05-01" @default.
- W1559940471 modified "2023-09-27" @default.
- W1559940471 title "BDNF integrates cognitive and physical resilience with immune function in successful aging (LYM4P.753)" @default.
- W1559940471 doi "https://doi.org/10.4049/jimmunol.192.supp.65.10" @default.
- W1559940471 hasPublicationYear "2014" @default.
- W1559940471 type Work @default.
- W1559940471 sameAs 1559940471 @default.
- W1559940471 citedByCount "0" @default.
- W1559940471 crossrefType "journal-article" @default.
- W1559940471 hasAuthorship W1559940471A5000503897 @default.
- W1559940471 hasAuthorship W1559940471A5005652638 @default.
- W1559940471 hasAuthorship W1559940471A5006850098 @default.
- W1559940471 hasAuthorship W1559940471A5032846886 @default.
- W1559940471 hasAuthorship W1559940471A5055648700 @default.
- W1559940471 hasAuthorship W1559940471A5057234091 @default.
- W1559940471 hasAuthorship W1559940471A5078687726 @default.
- W1559940471 hasConcept C126322002 @default.
- W1559940471 hasConcept C160539049 @default.
- W1559940471 hasConcept C169760540 @default.
- W1559940471 hasConcept C170493617 @default.
- W1559940471 hasConcept C203014093 @default.
- W1559940471 hasConcept C2778790584 @default.
- W1559940471 hasConcept C2779056147 @default.
- W1559940471 hasConcept C2779134260 @default.
- W1559940471 hasConcept C2779483572 @default.
- W1559940471 hasConcept C2984863031 @default.
- W1559940471 hasConcept C54355233 @default.
- W1559940471 hasConcept C71924100 @default.
- W1559940471 hasConcept C86803240 @default.
- W1559940471 hasConcept C8891405 @default.
- W1559940471 hasConceptScore W1559940471C126322002 @default.
- W1559940471 hasConceptScore W1559940471C160539049 @default.
- W1559940471 hasConceptScore W1559940471C169760540 @default.
- W1559940471 hasConceptScore W1559940471C170493617 @default.
- W1559940471 hasConceptScore W1559940471C203014093 @default.
- W1559940471 hasConceptScore W1559940471C2778790584 @default.
- W1559940471 hasConceptScore W1559940471C2779056147 @default.
- W1559940471 hasConceptScore W1559940471C2779134260 @default.
- W1559940471 hasConceptScore W1559940471C2779483572 @default.
- W1559940471 hasConceptScore W1559940471C2984863031 @default.
- W1559940471 hasConceptScore W1559940471C54355233 @default.
- W1559940471 hasConceptScore W1559940471C71924100 @default.
- W1559940471 hasConceptScore W1559940471C86803240 @default.
- W1559940471 hasConceptScore W1559940471C8891405 @default.
- W1559940471 hasIssue "1_Supplement" @default.
- W1559940471 hasLocation W15599404711 @default.
- W1559940471 hasOpenAccess W1559940471 @default.
- W1559940471 hasPrimaryLocation W15599404711 @default.
- W1559940471 hasRelatedWork W1559940471 @default.
- W1559940471 hasRelatedWork W1976885228 @default.
- W1559940471 hasRelatedWork W1995672598 @default.
- W1559940471 hasRelatedWork W2032375987 @default.
- W1559940471 hasRelatedWork W2039654885 @default.
- W1559940471 hasRelatedWork W2057892192 @default.
- W1559940471 hasRelatedWork W2183426161 @default.
- W1559940471 hasRelatedWork W2424197122 @default.
- W1559940471 hasRelatedWork W2523086335 @default.
- W1559940471 hasRelatedWork W2921745411 @default.
- W1559940471 hasVolume "192" @default.
- W1559940471 isParatext "false" @default.
- W1559940471 isRetracted "false" @default.
- W1559940471 magId "1559940471" @default.
- W1559940471 workType "article" @default.