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• W1559989154 abstract "In summary, evidence is presented that the mesocorticolimbic and nigrostriatal dopamine systems form functionally selective afferents to different parts of the basal ganglia and these inputs are paralleled by functionally selective outputs. The ventral striatal region of the nucleus accumbens and olfactory tubercle has a dopamine input that is critical for locomotor activation produced by psychomotor stimulant drugs and some non-drug states. These regions also appear critical for the reinforcing actions of psychomotor stimulants such as cocaine and amphetamine, and these regions may also be involved in the activation associated with non-drug rewards. Both psychomotor stimulant-induced locomotor activation and reinforcement may selectively involve dopamine D1 receptors. The functional efferents of this system appear to involve the region of the ventral pallidum and more specifically GABAergic mechanisms of the posterior medial (sublenticular) ventral pallidum. The relationship of this circuitry with the revised concept of the extended amygdala is an area of current work. The nigrostriatal dopamine system forms a functionally selective afferent system to the dorsal striatum and appears to be critical for the focused stereotyped behavior associated with high doses of psychomotor stimulants. This dopamine input also appears to be involved in non-drug-induced conditioned reaction time performance and may selectively involve dopamine D2 receptors. The functional efferents of this system appear to involve both direct and indirect GABAergic connections to the substantia nigra reticulata and dorsal pallidum, respectively. Activation of the GABAergic connection to the dorsal pallidum (indirect connection) appears to mimic the action of dopamine in the dorsal striatum, whereas activation of the GABAergic connection to the substantia nigra reticulata (direct connection) appears to modulate striatal dopamine function. These results show an important functional role for the globus pallidus in the output of the dorsal striatum and emphasize the parallel functional processing of both dorsal and ventral striatum." @default.
• W1559989154 created "2016-06-24" @default.
• W1559989154 creator A5001475191 @default.
• W1559989154 creator A5075246876 @default.
• W1559989154 date "1993-01-01" @default.
• W1559989154 modified "2023-10-16" @default.
• W1559989154 title "Chapter 14 Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system" @default.
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• W1559989154 doi "https://doi.org/10.1016/s0079-6123(08)61348-5" @default.
• W1559989154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8108549" @default.
• W1559989154 hasPublicationYear "1993" @default.
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