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- W1560155944 abstract "IL‐17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL‐17A–F) and five receptors (IL‐17RA–IL‐17RE) in mammals, these molecules have distinct primary amino acid structures with only minimal homology to other cytokine families. By far the best studied of these cytokines to date are IL‐17A and its receptor, IL‐17RA. IL‐17A is produced primarily by T cells, and is the hallmark cytokine of a newly defined T helper cell subset that appears to be involved in generation of autoimmunity. Despite its production by the adaptive immune system, IL‐17A exhibits proinflammatory activities similar to innate immune cytokines such as IL‐1β and TNF‐α and appears to play important and nonredundant roles in regulating granulocytes in vivo. As a result, IL‐17A also plays key roles in host defense. In contrast to the restricted expression of IL‐17A, the IL‐17RA receptor is ubiquitously expressed, and thus most cells are potential physiological targets of IL‐17A. This chapter describes the major molecular properties, biological activities, and known signaling pathways of the IL‐17 family, with an emphasis on IL‐17A and IL‐17RA." @default.
- W1560155944 created "2016-06-24" @default.
- W1560155944 creator A5041765138 @default.
- W1560155944 creator A5049895849 @default.
- W1560155944 creator A5064934325 @default.
- W1560155944 creator A5084338892 @default.
- W1560155944 date "2006-01-01" @default.
- W1560155944 modified "2023-10-14" @default.
- W1560155944 title "The IL‐17 Cytokine Family" @default.
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