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- W1560251014 abstract "The study of Escherichia coli lactose operon laid the foundation of modern molecular biology. It contributed to the elaboration of the concept of genetic regulation, proposed by Jacob and Monod almost 50 years ago, a model which survives essentially unchanged. The operon structure, consisting of structural and regulatory genes has been elaborated and their regulatory response to small molecules, such as inducer, glucose and cyclic AMP, have been elucidated. Gene regulation of the lactose operon led to the discovery of messenger ribonucleic acid (mRNA), to the identification of the Lac repressor and to the development of the theory of allostery. The lactose genes and its derivatives provide tools to a wide range of current applications in many fields of biology; they are the most commonly used reporter genes in the analysis of developmentally regulated systems, in the study of mutation frequencies and in functional genomics.Keywords:complementation;fusion proteins;repressor;gene regulation;cyclic AMP;allostery" @default.
- W1560251014 created "2016-06-24" @default.
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- W1560251014 date "2009-03-15" @default.
- W1560251014 modified "2023-10-18" @default.
- W1560251014 title "<i>Escherichia coli</i>Lactose Operon" @default.
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- W1560251014 doi "https://doi.org/10.1002/9780470015902.a0000849.pub2" @default.
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