Matches in SemOpenAlex for { <https://semopenalex.org/work/W156035434> ?p ?o ?g. }
- W156035434 abstract "Publisher Summary This chapter deals with assessment of neurotoxicity via chemical perturbation of axonal transport. Neurons, unlike other mammalian cells, have long processes that often extend considerable distances from the cell body. This extraordinary structural makeup poses special problems for intra- and intercommunication for these cells. Neurons with its large processes are quite vulnerable to a variety of toxic chemicals. However, it is not yet clear if the chemical inhibition of axonal transport is a primary effect or occurs secondary to structural changes in nerve fibers. A number of studies have shown that interference with cellular energy (ATP) generation, Ca2+ concentration, and cytoskeletal integrity disrupts the axonal transport system. Chemicals that block retrogradely transported trophic signals, disrupt MAPS, and perturb oncogene expression have adverse effect on axonal transport. This chapter summarizes current knowledge of axonal transport and the adverse effect of selected neurotoxic agents. It reviews the progress of axonal transport that has been made in the past 60 years. This chapter also discusses in detail the effect of selected neurotoxic chemicals on axonal transport." @default.
- W156035434 created "2016-06-24" @default.
- W156035434 creator A5049340317 @default.
- W156035434 date "1995-01-01" @default.
- W156035434 modified "2023-09-24" @default.
- W156035434 title "Assessment of Neurotoxicity via Chemical Perturbation of Axonal Transport" @default.
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