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- W1560367042 abstract "Background Standard treatment for unresectable advanced head and neck squamous cell carcinoma is chemoradiotherapy, which can be toxic, particularly among patients with coexisting medical conditions. We report our experience with the hypofractionated radiotherapy regimen Irradiation HypoFractionnée 2 Séances Quotidiennes (IHF2SQ). Methods We retrospectively reviewed 78 patients treated with the IHF2SQ regimen. Radiotherapy was administrated as 2 fractions of 3 Gy per day (days 1 and 3), during the first, third, fifth, and seventh week of treatment with concurrent platinum‐based chemotherapy. Results Tolerance was excellent. Forty‐one patients had complete or partial response. Median overall survival (OS) was 12.9 months and median progression‐free survival (PFS) was 10.3 months. One‐year OS, specific survival (SS), and PFS were 58%, 71%, 51.5%, respectively. Independent predictive factors increasing the PFS were response to chemoradiotherapy, male sex, and laryngeal tumor location. Conclusions This regimen is an alternative to conventional chemoradiotherapy with good response rates and acceptable toxicity for selected patients. © 2013 Wiley Periodicals, Inc. Head Neck 35: 1683–1688, 2013" @default.
- W1560367042 created "2016-06-24" @default.
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- W1560367042 date "2013-01-29" @default.
- W1560367042 modified "2023-10-17" @default.
- W1560367042 title "Hypofractionated palliative radiotherapy for advanced head and neck cancer: The IHF2SQ regimen" @default.
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- W1560367042 doi "https://doi.org/10.1002/hed.23219" @default.
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