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- W1560406476 abstract "The exposure of mammalian cells to UV light or other DNA-damaging agents induces several responses which may provide cellular defense mechanisms and also play a role in carcinogenesis. Employing a 257-base pair DNA fragment from the polyoma virus that contains the origin of replication and regulatory region of this virus, we have identified a set of DNA-binding proteins that are induced in normal rat fibroblasts at 6-24 h after UV exposure. These proteins bind to a specific octamer sequence (TGACAACA) designated the UV response element. Purification of these inducible proteins on a UV response element affinity column revealed a set of proteins, among which the major protein has a molecular weight of 40,000, which co-purify with c-fos but do not react with antibodies to c-jun-encoded proteins. These UV-induced proteins may, in concert with other cellular components, play a role in mediating specific cellular responses to DNA damage in mammalian cells." @default.
- W1560406476 created "2016-06-24" @default.
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- W1560406476 date "1990-09-01" @default.
- W1560406476 modified "2023-10-14" @default.
- W1560406476 title "Identification of ultraviolet-inducible proteins that bind to a TGACAACA sequence in the polyoma virus regulatory region." @default.
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