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- W1560434293 abstract "Binding of 125I-insulin to insulin receptor was studied at equilibrium using plasma membrane protein, from human placenta, solubilized in Triton X-100. Measured at 1 nM 125I-insulin, the amount of radioligand bound specifically was dependent upon pH, the optimal association at 4 degrees C occurring in the pH range 8.2-8.7. The Adair equation was employed for analysis of binding isotherms generated at several pH values for concentrations of radioligand varying from 0.01-8.0 nM. Association constants derived from these analyses showed the same pH dependence described above and were found to be independent of receptor concentration. Hill plots derived from these titrations consistently yielded Hill coefficients of 1 and Scatchard plots gave virtually straight lines. Close correspondence was found between theoretical analyses and observations under all experimental conditions and graphical methods employed. These results are consistent with a single class of noninteracting 125I-insulin binding sites on the solubilized insulin receptor." @default.
- W1560434293 created "2016-06-24" @default.
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- W1560434293 date "1983-06-01" @default.
- W1560434293 modified "2023-09-26" @default.
- W1560434293 title "Binding of insulin to solubilized insulin receptor from human placenta. Evidence for a single class of noninteracting binding sites." @default.
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- W1560434293 doi "https://doi.org/10.1016/s0021-9258(18)32200-2" @default.
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