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- W1560632733 abstract "Abstract The development of the pancreas and determination of endocrine cell fate are controlled by a highly complex interplay of signaling events and transcriptional networks. It is now known that an interconnected epigenetic program is also required to drive these processes. Recent studies using genome‐wide approaches have implicated epigenetic regulators, such as DNA and histone‐modifying enzymes and noncoding RNAs , to play critical roles in pancreas development and the maintenance of cell identity and function. Furthermore, genome‐wide analyses have implicated epigenetic changes as a casual factor in the pathogenesis of diabetes. In the future, genomic approaches to further our understanding of the role of epigenetics in endocrine cell development and function will be useful for devising strategies to produce or manipulate β‐cells for therapies of diabetes. WIREs Syst Biol Med 2015, 7:1–11. doi: 10.1002/wsbm.1287 This article is categorized under: Biological Mechanisms > Cell Fates Developmental Biology > Lineages Developmental Biology > Stem Cell Biology and Regeneration" @default.
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- W1560632733 date "2015-01-01" @default.
- W1560632733 modified "2023-10-09" @default.
- W1560632733 title "A systems view of epigenetic networks regulating pancreas development and β‐cell function" @default.
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- W1560632733 doi "https://doi.org/10.1002/wsbm.1287" @default.
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