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- W1560785021 abstract "In budding yeast, Mps3 is essential for duplicating the spindle pole body (SPB) and is critical for promoting chromosome motion during meiosis. It is a member of the SUN (Sad1-Unc-84) domain family of proteins that localizes to the inner nuclear envelope (NE) in many eukaryotic organisms and preferentially localizes to the SPB in vegetative growth; in meiotic prophase I, it redistributes to many sites within the NE. We constructed an mps3 mutant, mps3-sun, which completely lacks the SUN domain. Surprisingly, the mps3-sun mutation does not disrupt SPB duplication or Mps3 localization to the NE in meiosis. However, it confers several defects during meiotic prophase I including reduced chromosome motion, premature synapsis between homologous chromosomes, and reduced levels of closely juxtaposed homologous loci in pachytene. These findings suggest that in meiosis, the Mps3 SUN domain is important for modulating chromosome motion events that act in meiotic chromosome juxtaposition and by extension, promoting proper morphogenesis of the synaptonemal complex." @default.
- W1560785021 created "2016-06-24" @default.
- W1560785021 creator A5041592902 @default.
- W1560785021 creator A5054047848 @default.
- W1560785021 date "2011-10-23" @default.
- W1560785021 modified "2023-09-27" @default.
- W1560785021 title "Mps3 SUN domain is important for chromosome motion and juxtaposition of homologous chromosomes during meiosis" @default.
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- W1560785021 doi "https://doi.org/10.1111/j.1365-2443.2011.01554.x" @default.
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