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• W1560873753 abstract "TNF is a potent cytokine with an important role in the regulation of a multitude of cellular responses and in coordinating immune and inflammatory reactions. TNF exerts its effects by binding to the TNFR1- and TNFR2-specific cell surface receptors, which activate a number of intracellular signaling cascades including the nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase pathways. Activation of NF-kappaB mediates many of the functions of TNF by transmitting information from the cell surface TNF receptors to the nucleus, where it coordinates a gene expression program that allows the cell to survive and elicit its responses. The intimate interplay of TNF with the NF-kappaB signaling pathway is highlighted by results obtained in transgenic and knockout mice with defects in NF-kappaB signaling components, where TNF has been shown to contribute to different pathologies observed in these mice. This chapter focuses on the function of TNF in pathologies induced by NF-kappaB deficiency and discusses the implications of these findings for our understanding of inflammatory diseases." @default.
• W1560873753 created "2016-06-24" @default.
• W1560873753 creator A5002366601 @default.
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• W1560873753 date "2010-01-01" @default.
• W1560873753 modified "2023-10-12" @default.
• W1560873753 title "Role of TNF in Pathologies Induced by Nuclear Factor &kappa;B Deficiency" @default.
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• W1560873753 doi "https://doi.org/10.1159/000289198" @default.
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