FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1560970554> ?p ?o ?g. }

• W1560970554 endingPage "2169" @default.
• W1560970554 startingPage "2162" @default.
• W1560970554 abstract "We have isolated a previously unrecognized heparin-dependent inhibitor of thrombin from human plasma. The inhibitor, designated heparin cofactor II (HCII), was purified to homogeneity with sulfated-dextran, DEAE-Sepharose, heparin-Sepharose and Sephadex G-150. HCII is a glycoprotein consisting of a single polypeptide chain with a Mr = 65,600 as determined by sedimentation equilibrium analysis. Other physical properties include s20,w = 4.31 S; Stokes radius = 34 A; E280 1% = 11.7; and pI = 4.95 to 5.15. The purified inhibitor is not precipitated by antibodies directed against seven other plasma protease inhibitors, including antithrombin III (ATIII). HCII blocks the proteolytic and amidolytic activities of thrombin by forming a covalent, 1:1 molar complex with the protease. The second-order rate constant for inhibition of thrombin by purified HCII increases from 5.0 X 10(5) M-1 min-1 in the absence of heparin to 4.5 x 10(8) M-1 min-1 at optimal heparin concentrations of 0.8 to 1.0 unit/ml. In comparison with ATIII, HCII is a relatively ineffective inhibitor of coagulation factor Xa." @default.
• W1560970554 created "2016-06-24" @default.
• W1560970554 creator A5002362253 @default.
• W1560970554 creator A5061002869 @default.
• W1560970554 creator A5086875288 @default.
• W1560970554 date "1982-03-01" @default.
• W1560970554 modified "2023-10-15" @default.
• W1560970554 title "Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma." @default.
• W1560970554 cites W1014581649 @default.
• W1560970554 cites W1504726355 @default.
• W1560970554 cites W1518304924 @default.
• W1560970554 cites W1524312435 @default.
• W1560970554 cites W1527081709 @default.
• W1560970554 cites W1528764883 @default.
• W1560970554 cites W1531550096 @default.
• W1560970554 cites W1534197062 @default.
• W1560970554 cites W1574834577 @default.
• W1560970554 cites W1580023435 @default.
• W1560970554 cites W1594750244 @default.
• W1560970554 cites W1891400877 @default.
• W1560970554 cites W1968684223 @default.
• W1560970554 cites W1971085246 @default.
• W1560970554 cites W1973956782 @default.
• W1560970554 cites W1974890290 @default.
• W1560970554 cites W1975781625 @default.
• W1560970554 cites W1989989356 @default.
• W1560970554 cites W1994517550 @default.
• W1560970554 cites W1995135269 @default.
• W1560970554 cites W1998573243 @default.
• W1560970554 cites W2003539081 @default.
• W1560970554 cites W2004746423 @default.
• W1560970554 cites W2020221662 @default.
• W1560970554 cites W2020910725 @default.
• W1560970554 cites W2032711004 @default.
• W1560970554 cites W2038058775 @default.
• W1560970554 cites W2041089953 @default.
• W1560970554 cites W2053818661 @default.
• W1560970554 cites W2068224839 @default.
• W1560970554 cites W2068660116 @default.
• W1560970554 cites W2069661372 @default.
• W1560970554 cites W2071344661 @default.
• W1560970554 cites W2076305871 @default.
• W1560970554 cites W2100837269 @default.
• W1560970554 cites W2119586900 @default.
• W1560970554 cites W2127089463 @default.
• W1560970554 cites W2132184473 @default.
• W1560970554 cites W4246793858 @default.
• W1560970554 cites W4251685699 @default.
• W1560970554 doi "https://doi.org/10.1016/s0021-9258(18)34900-7" @default.
• W1560970554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6895893" @default.
• W1560970554 hasPublicationYear "1982" @default.
• W1560970554 type Work @default.
• W1560970554 sameAs 1560970554 @default.
• W1560970554 citedByCount "395" @default.
• W1560970554 countsByYear W15609705542012 @default.
• W1560970554 countsByYear W15609705542013 @default.
• W1560970554 countsByYear W15609705542014 @default.
• W1560970554 countsByYear W15609705542015 @default.
• W1560970554 countsByYear W15609705542016 @default.
• W1560970554 countsByYear W15609705542017 @default.
• W1560970554 countsByYear W15609705542018 @default.
• W1560970554 countsByYear W15609705542019 @default.
• W1560970554 countsByYear W15609705542020 @default.
• W1560970554 countsByYear W15609705542022 @default.
• W1560970554 countsByYear W15609705542023 @default.
• W1560970554 crossrefType "journal-article" @default.
• W1560970554 hasAuthorship W1560970554A5002362253 @default.
• W1560970554 hasAuthorship W1560970554A5061002869 @default.
• W1560970554 hasAuthorship W1560970554A5086875288 @default.
• W1560970554 hasBestOaLocation W15609705541 @default.
• W1560970554 hasConcept C126322002 @default.
• W1560970554 hasConcept C181199279 @default.
• W1560970554 hasConcept C185592680 @default.
• W1560970554 hasConcept C197957613 @default.
• W1560970554 hasConcept C2777292125 @default.
• W1560970554 hasConcept C2777557582 @default.
• W1560970554 hasConcept C2778162025 @default.
• W1560970554 hasConcept C2779026020 @default.
• W1560970554 hasConcept C3020134792 @default.
• W1560970554 hasConcept C43617362 @default.
• W1560970554 hasConcept C55493867 @default.
• W1560970554 hasConcept C71924100 @default.
• W1560970554 hasConcept C89560881 @default.
• W1560970554 hasConceptScore W1560970554C126322002 @default.
• W1560970554 hasConceptScore W1560970554C181199279 @default.
• W1560970554 hasConceptScore W1560970554C185592680 @default.
• W1560970554 hasConceptScore W1560970554C197957613 @default.
• W1560970554 hasConceptScore W1560970554C2777292125 @default.
• W1560970554 hasConceptScore W1560970554C2777557582 @default.
• W1560970554 hasConceptScore W1560970554C2778162025 @default.
• W1560970554 hasConceptScore W1560970554C2779026020 @default.
• W1560970554 hasConceptScore W1560970554C3020134792 @default.
• W1560970554 hasConceptScore W1560970554C43617362 @default.
• W1560970554 hasConceptScore W1560970554C55493867 @default.
• W1560970554 hasConceptScore W1560970554C71924100 @default.
• W1560970554 hasConceptScore W1560970554C89560881 @default.
• W1560970554 hasIssue "5" @default.
• W1560970554 hasLocation W15609705541 @default.

• next