Matches in SemOpenAlex for { <https://semopenalex.org/work/W1561006857> ?p ?o ?g. }
- W1561006857 endingPage "784" @default.
- W1561006857 startingPage "772" @default.
- W1561006857 abstract "Purpose In brain tumor dynamic susceptibility contrast (DSC)‐MRI studies, multiecho acquisition methods are used to quantify the dynamic changes in T 1 and T 2 * that occur when contrast agent (CA) extravasates. Such methods also enable the estimation of the effective tissue CA transverse relaxivity. The goal of this study was to evaluate the sensitivity of the transverse relaxivity at tracer equilibrium (TRATE) to tumor cytoarchitecture. Methods Computational and in vitro studies were used to evaluate the biophysical basis of TRATE. In 9L, C6, and human brain tumors, TRATE, the apparent diffusion coefficient ( ADC) , the CA transfer constant ( K trans ), the extravascular extracellular volume fraction ( v e ), and histological data were compared. Results Simulations and in vitro results indicate that TRATE is highly sensitive to variations in cellular properties such as cell size and density. The histologic cell density and TRATE values were significantly higher in 9L tumors as compared to C6 tumors. In animal and human tumors, a voxel‐wise comparison of TRATE with ADC , v e , and K trans maps showed low spatial correlation. Conclusion The assessment of TRATE is clinically feasible and its sensitivity to tissue cytoarchitectural features not present in other imaging methods indicate that it could potentially serve as a unique structural signature or “trait” of cancer. Magn Reson Med 74:772–784, 2015. © 2014 Wiley Periodicals, Inc." @default.
- W1561006857 created "2016-06-24" @default.
- W1561006857 creator A5004349650 @default.
- W1561006857 creator A5009594320 @default.
- W1561006857 creator A5017521861 @default.
- W1561006857 creator A5038716313 @default.
- W1561006857 creator A5042841835 @default.
- W1561006857 creator A5049990994 @default.
- W1561006857 creator A5055725087 @default.
- W1561006857 date "2014-09-16" @default.
- W1561006857 modified "2023-10-05" @default.
- W1561006857 title "Assessing tumor cytoarchitecture using multiecho DSC-MRI derived measures of the transverse relaxivity at tracer equilibrium (TRATE)" @default.
- W1561006857 cites W1481725770 @default.
- W1561006857 cites W1964906439 @default.
- W1561006857 cites W1966632689 @default.
- W1561006857 cites W1970124993 @default.
- W1561006857 cites W1971524605 @default.
- W1561006857 cites W1977355015 @default.
- W1561006857 cites W1980086703 @default.
- W1561006857 cites W1993998781 @default.
- W1561006857 cites W2001053265 @default.
- W1561006857 cites W2013029458 @default.
- W1561006857 cites W2016337569 @default.
- W1561006857 cites W2017933173 @default.
- W1561006857 cites W2018577646 @default.
- W1561006857 cites W2019540655 @default.
- W1561006857 cites W2019902751 @default.
- W1561006857 cites W2021288523 @default.
- W1561006857 cites W2022912277 @default.
- W1561006857 cites W2027172854 @default.
- W1561006857 cites W2027633394 @default.
- W1561006857 cites W2030003406 @default.
- W1561006857 cites W2030109510 @default.
- W1561006857 cites W2031103743 @default.
- W1561006857 cites W2034187868 @default.
- W1561006857 cites W2035213115 @default.
- W1561006857 cites W2035532224 @default.
- W1561006857 cites W2036229827 @default.
- W1561006857 cites W2038195888 @default.
- W1561006857 cites W2038257557 @default.
- W1561006857 cites W2048513640 @default.
- W1561006857 cites W2050167188 @default.
- W1561006857 cites W2060320421 @default.
- W1561006857 cites W2064533924 @default.
- W1561006857 cites W2070540496 @default.
- W1561006857 cites W2079716456 @default.
- W1561006857 cites W2085512859 @default.
- W1561006857 cites W2088485981 @default.
- W1561006857 cites W2090054278 @default.
- W1561006857 cites W2093174485 @default.
- W1561006857 cites W2100481498 @default.
- W1561006857 cites W2114626889 @default.
- W1561006857 cites W2115424808 @default.
- W1561006857 cites W2116385030 @default.
- W1561006857 cites W2128687105 @default.
- W1561006857 cites W2134431790 @default.
- W1561006857 cites W2142199963 @default.
- W1561006857 cites W2147535764 @default.
- W1561006857 cites W2152211251 @default.
- W1561006857 doi "https://doi.org/10.1002/mrm.25435" @default.
- W1561006857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4362846" @default.
- W1561006857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25227668" @default.
- W1561006857 hasPublicationYear "2014" @default.
- W1561006857 type Work @default.
- W1561006857 sameAs 1561006857 @default.
- W1561006857 citedByCount "24" @default.
- W1561006857 countsByYear W15610068572015 @default.
- W1561006857 countsByYear W15610068572016 @default.
- W1561006857 countsByYear W15610068572017 @default.
- W1561006857 countsByYear W15610068572019 @default.
- W1561006857 countsByYear W15610068572020 @default.
- W1561006857 countsByYear W15610068572021 @default.
- W1561006857 countsByYear W15610068572022 @default.
- W1561006857 countsByYear W15610068572023 @default.
- W1561006857 crossrefType "journal-article" @default.
- W1561006857 hasAuthorship W1561006857A5004349650 @default.
- W1561006857 hasAuthorship W1561006857A5009594320 @default.
- W1561006857 hasAuthorship W1561006857A5017521861 @default.
- W1561006857 hasAuthorship W1561006857A5038716313 @default.
- W1561006857 hasAuthorship W1561006857A5042841835 @default.
- W1561006857 hasAuthorship W1561006857A5049990994 @default.
- W1561006857 hasAuthorship W1561006857A5055725087 @default.
- W1561006857 hasBestOaLocation W15610068571 @default.
- W1561006857 hasConcept C105702510 @default.
- W1561006857 hasConcept C121332964 @default.
- W1561006857 hasConcept C154945302 @default.
- W1561006857 hasConcept C163895629 @default.
- W1561006857 hasConcept C185592680 @default.
- W1561006857 hasConcept C2776194525 @default.
- W1561006857 hasConcept C2989005 @default.
- W1561006857 hasConcept C41008148 @default.
- W1561006857 hasConcept C46141821 @default.
- W1561006857 hasConcept C502942594 @default.
- W1561006857 hasConcept C54170458 @default.
- W1561006857 hasConcept C71924100 @default.
- W1561006857 hasConcept C86803240 @default.
- W1561006857 hasConceptScore W1561006857C105702510 @default.
- W1561006857 hasConceptScore W1561006857C121332964 @default.