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- W1561036277 abstract "Abstract Toll-like receptors (TLR) induce NF-κB dependent or independent cytokine/chemokine secretion and contribute to the establishment of innate and adaptive immune response. When nucleic acid ligands were given in vivo they were attacked by endonucleases and have low uptake efficiency into immune cells due to premature adsorption to serum proteins. Polysaccharides (PS) from edible mushrooms were characterized as immunostimulatory amphiphilic macromolecules. Due to their β-glucan moieties, we have established that these PS`s are recognized and induce TLR2 (but not via NOD-1 or NOD2) mediated activation (as evidenced by NO, TNFα IL6 responses) and can be naturally targeted through this extracellular receptor. Next, we complexed PS with pI:C, R848 and CpG ODN, a TLR3,7/8, and 9 ligands. Different ratio of these nanocomplexes displayed a strong synergism as evidenced by a Th1-biased cytokine secretion and NO production compared to their alone counterparts. This study showed that natural PS is an immunostimulatory compound by itself, and furthermore, it could be used to effectively complex and deliver nucleic acid based TLR ligands to relevant immune cells. The targeted delivery of the generated nanocomplexes led to a more pronounced immune activation that is not achievable either of the stimulants when given alone." @default.
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- W1561036277 date "2010-04-01" @default.
- W1561036277 modified "2023-10-14" @default.
- W1561036277 title "Natural polysaccharides and nucleic acid based TLR ligand nanocomplexes improves immune response (89.41)" @default.
- W1561036277 doi "https://doi.org/10.4049/jimmunol.184.supp.89.41" @default.
- W1561036277 hasPublicationYear "2010" @default.
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